STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tpxThiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (168 aa)    
Predicted Functional Partners:
dgkA
Diacylglycerol kinase recycles diacylglycerol produced during the turnover of membrane phospholipids. May play a role in adaptability to environmental stress conditions such as acid tolerance, elevated temperatures and high osmolarity. Features two transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
       0.820
sodA
Superoxide dismutase [Mn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.789
CAZ98749.1
Hypothetical membrane protein; Protein that could belong to the alkaline phosphatase superfamily; Contains five N-terminal transmembrane segments; Localized in the cytoplasmic membrane; Hypothetical protein.
       0.605
trxA-4
Thioredoxin is a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase; Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.595
CAZ95878.1
Intracellular peptidase, family C56; The catalytic diad of theses peptidases is constituted by two consecutive conserved residues, Cys His. The enzyme forms a hexameric ring structure, and the active site is proposed to be formed at the interface between three pairs of monomers; The peptidase monomer adopts a alpha/beta hydrolase fold; Belongs to the family 56 of the cysteine peptidases (C56); Localized in the cytoplasm; Specificity unclear.
  
 
 0.580
CAZ98744.1
Peroxiredoxins are thiol peroxidase involved in redox regulation of the cell. Can reduce H(2)O(2), short chain organic, fatty acid, and phospholipid hydroperoxides. The peroxidase reaction comprises two steps centered around a redox-active cysteine called the peroxidatic cysteine. It oxidized the peroxide substrate to S-hydroxycysteine (a sulfenic acid). The second step is the regeneration of cysteine from S-hydroxycysteine. This regeneration is due to thiol-containing reductants such as thioredoxin; Localized in the cytoplasm; Specificity unclear.
  
  
 0.569
ftsK
FtsK is a DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP-dependent manner by generating positive supercoils in front of it and negative supercoils behind it. It forms a hexamer. Features four transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
       0.518
CAZ96007.1
Metal dependent transcriptional regulator binds two divalent metal effectors per monomer via an dimerization domain with two metal-binding sites, upon which allosteric changes occur that moderate binding to the cognate DNA operators of a target gene via a N-terminal DtxR-type HTH domain; Contains an C-terminal SH3-like domain that characterizes the Fe(II)-regulators. It may act to stabilizing the dimeric form of the repressor; Family membership.
  
  
 0.481
CAZ98746.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.479
CAZ98751.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 19 and 20; Localized in the periplasmic space; Conserved hypothetical protein.
       0.464
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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