STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thlAAcetyl-CoA acetyltransferase is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or mevalonate biogenesis. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)    
Predicted Functional Partners:
fadN
3-Hydroxyl-CoA dehydrogenase / Enoyl-CoA hydratase; Modular protein containing a N-terminal 3-Hydroxyl-CoA dehydrogenase domain and a C-terminal Enoyl-CoA hydratase domain. In Bacillus subtilis, this protein was formerly known as YusL, and has been renamed FadN by Matsuoka et al (JBC, 2007). FadN is involved in fatty acid degradation. 3-Hydroxyl-CoA dehydrogenase catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. It uses NAD as cofactor. Enoyl-CoA hydratase catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. Localized in the cytoplasm; High confidence in [...]
 
 0.999
hbdA
The 3-Hydroxybutyryl-CoA dehydrogenase is involved in butyrate/butanol-producing pathway. It converts the (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 0.998
CAZ97268.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 21 and 22; Localized in the periplasmic space; Conserved hypothetical protein.
  
 
 0.963
acxA
Acyl-coA oxidase, with FAD cofactor, converts acyl-CoA into trans-2-enoyl-CoA; Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18); Family membership.
  
 0.958
CAZ94724.1
Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein). These enzymes are homodimers containing one molecule of FAD; Localized in the cytoplasm; Specificity unclear.
  
 0.958
acs
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
  
 
 0.957
gltA
The citrate synthase is the enzyme that catalyzes an important reaction in both energy generation and carbon assimilation, the synthesis of citrate from oxaloacetate and acetyl-CoA in an aldol condensation, that is the first reaction of the tricarboxylic acid cycle (Krebs' cycle). It can directly form a carbon-carbon bond in the absence of metal ion cofactors; Allosterically inhibited by NADH; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.935
scoB
3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoB is the subunit B. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.933
accC
Acetyl-coenzyme A carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 0.930
scoA
3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoA is the subunit A. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.928
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.