STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aldA-3Lactaldehyde dehydrogenase is involved in the catabolism of L-fucose and L-rhamnose and is induced by these sugars. AldA catalyzes the NAD-dependent oxidation of lactaldehyde into lactate; Forms a tetramer; Belongs to the aldehyde dehydrogenase fold family; Localized in the cytoplasm; High confidence in function and specificity. (484 aa)    
Predicted Functional Partners:
maeB
Bifunctional protein: Malic enzyme (N-terminal domain, 1 to 550) and Phosphate acetyl/butaryl transferase (C-terminal domain, 550 to 765); High confidence in function and specificity.
  
 
 0.942
CAZ95842.1
Oxydoreductase NADPH dependent; Belongs to the aldo/keto reductase 1 family; Localized in the cytoplasm; Family membership.
 
 
 0.915
pykA
Pyruvate kinase (PK) catalyzes the final step in glycolysis (Embden-Meyerhof pathway), the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP. PK forms a homotetramer and requires both magnesium and potassium ions for its activity. PK helps control the rate of glycolysis, along with phosphofructokinase and hexokinase. PK possesses allosteric sites for numerous effectors; Localized in the cytoplasm; High confidence in function and specificity.
   
 0.914
ghrA
Glyoxylate/hydroxypyruvate reductase A catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively; Contains a glycine-rich region located in the central section corresponding to the NAD-binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.913
lldD1
L-lactate dehydrogenase is involved in L-lactate degradation converting the L-lactate to pyruvate; Uses flavin mononucleotide (FMN) as prosthetic group; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 
 0.908
lldD2
L-lactate dehydrogenase is involved in L-lactate degradation converting the L-lactate to pyruvate; Uses flavin mononucleotide (FMN) as prosthetic group; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 
 0.908
pycA
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
 
 
 
 0.908
pdhB
Pyruvate dehydrogenase, E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
 0.908
pdhA
Pyruvate dehydrogenase, E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.907
ddh
NAD-dependent 2-hydroxyacid dehydrogenases are enzymes which seem to be specific for the D-isomer of their substrate. these enzymes are composed of a substrate-binding domain and a NAD-binding domain (Rossman fold); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.906
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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