STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
uxaAAltronate hydrolase or Altronic acid hydratase converts the altronic acid to 2-keto-2-deoxygluconate; it is catalytically inactive in the absence of Fe2+, Mn2+, and beta-mercaptoethanol. Synergistic activation of enzyme is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre; Contains an N-terminal SAF domain; Localized in the cytoplasm; High confidence in function and specificity. (550 aa)    
Predicted Functional Partners:
uxaB
Altronate oxidoreductase or Tagaturonate reductase catalyzes the NAD-dependent reduction of altronate into tagaturonate; Belongs to the Long-chain mannitol dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.994
uxuA1
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 
 0.938
uxuA2
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
 
 0.936
kduD2
The 2-keto-3-deoxygluconate oxidoreductase or 2-deoxy-D-gluconate 3-dehydrogenase is involved in the pectin degradation in the pectinolytic microorganisms; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.902
kduD1
2-deoxy-D-gluconate-3-dehydrogenase; Enzyme that belongs to the Pentose and glucuronate interconversions pathway; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.902
iolC
The 5-dehydro-2-deoxygluconokinase catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP); Belongs to the carbohydrate kinase PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.853
kdgK1
2-dehydro-3-deoxygluconokinase; The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP) in the Entner-Doudoroff pathway. KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; Belongs to the Carbohydrate kinase, PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.852
kdgK2
2-dehydro-3-deoxygluconokinase; The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP)in the Entner-Doudoroff Pathway. KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; Belongs to the Carbohydrate kinase, PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.851
uxaC
Uronate isomerase catalyzes the reaction D-glucuronate to D-fructuronate and also converts D-galacturonate to D-tagaturonate. It is involved in the pentose and glucuronate interconversion. Localized in the cytoplasm; High confidence in function and specificity.
  
 0.846
CAZ98818.1
Amidohydrolase 2 family protein; Belongs to the metal-dependent hydrolase superfamily, Amidohydrolase 2 family; Localized in the cytoplasm; Family membership.
 
   
 0.820
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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