STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kdgK22-dehydro-3-deoxygluconokinase; The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP)in the Entner-Doudoroff Pathway. KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; Belongs to the Carbohydrate kinase, PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity. (346 aa)    
Predicted Functional Partners:
eda
KHG/KDPG aldolase is a bifunctional enzyme catalyzing the interconversion of 4-hydroxy-2-oxoglutarate into pyruvate and glyoxylate (4-Hydroxy-2-oxoglutarate aldolase activity) and the interconversion of 6-phospho-2-dehydro-3-deoxy-D-gluconate into pyruvate and glyceraldehyde 3-phosphate (Phospho-2-dehydro-3-deoxygluconate aldolase activity). This enzyme is involved in the Entner-Doudoroff pathway and in the glyoxylate and dicarboxylate metabolism; Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the [...]
 
 0.994
dgoA
2-Dehydro-3-deoxy-6-phosphogalactonate aldolase catalyzes the third step of the D-galactonate catabolism: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. Belongs to the class I aldolase whose catalytic mechanism involves the formation of a Schiff-base intermediate between the substrate and the epsilon-amino group of a lysine residue. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.991
iolC
The 5-dehydro-2-deoxygluconokinase catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP); Belongs to the carbohydrate kinase PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 
0.904
kdgK1
2-dehydro-3-deoxygluconokinase; The 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP) in the Entner-Doudoroff pathway. KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the glycolysis and therefore use polymers, like pectin and xylan as carbon sources; Belongs to the Carbohydrate kinase, PfkB family, 2-dehydro-3-deoxygluconokinase (KdgK) subfamily; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 
0.900
rpeA
Ribulose-phosphate 3-epimerase converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Pentose phosphate pathway; Adopts a a TIM barrel fold; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.870
uxaA
Altronate hydrolase or Altronic acid hydratase converts the altronic acid to 2-keto-2-deoxygluconate; it is catalytically inactive in the absence of Fe2+, Mn2+, and beta-mercaptoethanol. Synergistic activation of enzyme is seen in the presence of both iron and manganese ions, suggesting that the enzyme may have two ion binding sites. Mn2+ appears to be part of the enzyme active centre; Contains an N-terminal SAF domain; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.851
uxuA1
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
 
  
 0.838
kduD2
The 2-keto-3-deoxygluconate oxidoreductase or 2-deoxy-D-gluconate 3-dehydrogenase is involved in the pectin degradation in the pectinolytic microorganisms; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.818
kduD1
2-deoxy-D-gluconate-3-dehydrogenase; Enzyme that belongs to the Pentose and glucuronate interconversions pathway; Belongs to the short-chain dehydrogenases/reductases (SDR) family, Glucose/ribitol dehydrogenase subfamily; Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.818
uxuA2
Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.
    
 0.817
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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