STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
gntK2Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity. (170 aa)    
Predicted Functional Partners:
gndA
6-Phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
  
 0.993
pglA
6-Phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
  
 0.961
gntK1
Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 
0.915
miaA
tRNA isopentenyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
      0.913
gnlA
Gluconolactonases hydrolyze the gluconolactone, formed either by the glucose oxidoreductase or by the glucose dehydrogenase in aerobic conditions, to gluconate; Contains a putative lipoprotein signal peptide cleaved between the residues 20 and 21; Possibly localized in the outer membrane; High confidence in function and specificity.
    
 0.905
CAZ94658.1
Gluconolactonases hydrolyze the gluconolactone formed by glucose oxidoreductase. The proximity of the galactonate dehydratase gene dgoD suggests that this lactonase would be specific for D-galactono-1,4-lactone instead of gluconolactone; Signal peptide cleaved between the residues 19 and 20; Localized in the periplasm; Specificity unclear.
    
 0.905
rpiA
Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
    
 0.905
CAZ95093.1
Conserved protein distantly related to 6-phosphogluconolactonases; Localized in the cytoplasm; Function unclear.
     
 0.900
CAZ97731.1
3-carboxymuconate cyclase-like protein; Possible 3-carboxymuconate cyclase, which converts by isomerisation the 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-carboxy-cis,cis-muconate; Contains a signal peptide of lipoprotein cleaved between the residues 19 and 20; Belongs to the cycloisomerase 2 family; Localized in the cytoplasmic membrane; Family membership.
     
 0.900
CAZ95197.1
NAD(P)-dependent oxidoreductase that adopts a Rossmann fold; belongs to the GFO/IDH/MOCA family; Localized in the cytoplasm; Specificity unclear.
 
    
 0.809
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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