STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rrnARibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (301 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate (). This is the second step in the de novo biosynthesis of pyrimidine nucleotides; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
       0.820
pyrR1
Bifunctional protein pyrR; PyrR regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. It forms in equilibrium a homodimer and a homohexamer. Localized in the cytoplasm; High confidence in function and specificity.
       0.820
CAZ94574.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.819
CAZ95234.1
DNA/RNA non-specific endonuclease; Endonuclease acting on both DNA and RNA. Cleaves double-stranded and single-stranded nucleic acids and requires a divalent ion such as magnesium for its activity. A histidine has been shown to be essential for the activity, located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion; Contains a N-terminal transmembrane segment; Localized in the cytoplasmic membrane; Specificity unclear.
   
   0.816
CAZ98094.1
DNA/RNA non-specific endonuclease; Protein containing a N-terminal domain of unknown function and a C-terminal endonuclease domain. This endonuclease acts on both DNA and RNA, cleaves double-stranded and single-stranded nucleic acids and requires a divalent ion such as magnesium for its activity. A catalytic site is located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion; Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 21 and 22; LOcalized in the outer membrane; Function unclear.
   
   0.816
CAZ98848.1
DNA/RNA non-specific endonuclease; Endonuclease acting on both DNA and RNA. Cleaves double-stranded and single-stranded nucleic acids and requires. A catalytic histidine is located in a conserved region which also contains an aspartate that could be implicated in the binding of the divalent ion; Uses a divalent ion such as magnesium as cofactor; Localized in the cytoplasm; Specificity unclear.
   
   0.816
CAZ94573.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.787
argS
Arginyl-tRNA synthetase also called Arginine-tRNA ligase is a monomeric enzyme that catalyzes the transfer of arginine to specific tRNA molecule as the first step in protein biosynthesis; Belongs to the class-I aminoacyl-tRNA synthetase family; Localized in the cytoplasm; High confidence in function and specificity.
  
  
 0.705
pdxH1
Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
       0.618
rpsA
Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
  
    0.556
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.