STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (138 aa)    
Predicted Functional Partners:
aroE
Shikimate dehydrogenase catalyzes the fourth step of The shikimate pathway. In a NADP+-dependent reaction, AroE converts the shikimate to 3-dehydroshikimate. The N-terminal domain is the shikimate-binding domain and consists of a mainly parallel six-stranded beta-sheet and six alpha-helices. The C-terminal NADP-binding domain adopts a nearly canonical Rossmann fold; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.986
aroB2
3-Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
 0.974
aroB1
3-Dehydroquinate synthase is involved in the biosynthesis of aromatic amino acids. It catalyzes the second step of the shikimate pathway, the formation of dehydroquinate and orthophosphate from 3-deoxy-D-arabino heptulosonic 7 phosphate. It forms a monomer and binds NAD and divalent metal cation as cofactors. Localized in the cytoplasm; High confidence in function and specificity.
 
 0.942
aroGH
Bifunctional enzyme including 3-deoxy-7-phosphoheptulonate synthase (DAHP synthase) in N-terminus and chorismate mutase in C-terminus. DAHP synthase catalyzes the first step in the common pathway leading to the biosynthesis of aromatic compounds, the stereospecific condensation of phosphoenolpyruvate and D-erythrose-4-phosphate giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). Chorismate mutase catalyzes the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. Localized in the cytoplasm; High confidence in function and speci [...]
 
   
 0.668
tigA
Trigger factor (TF) is involved in protein export. It acts as an ATP-independent chaperone by binding to nascent polypeptide chains via ribosomal protein L23 (RplE) and maintaining the newly synthesized protein in an open conformation. Trigger Factor also displays a peptidyl-prolyl-cis-trans-isomerase (PPIase) activity in vitro. TF is composed of an N-terminal domain that mediates association with the large ribosomal subunit, a central substrate binding and PPIase domain with homology to FKBP proteins, and a C-terminal domain of unknown function. TF forms homodimer and monomer; Localiz [...]
  
  
 0.615
secG
Protein-export membrane protein secG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.
  
    0.593
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
   
 0.547
CAZ94598.1
Conserved hypothetical periplasmic protein; Contains a signal peptide cleaved between the residues 32 and 33; Localized in the periplasmic space; Conserved hypothetical protein.
       0.545
rplM
Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
    0.517
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.495
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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