STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cvrACell volume regulation protein A participates in control of cell volume in low-osmolarity conditions. It belongs to the Na/H antiporters. This integral membrane protein also features a C-terminal TrkA-C domain which may bind an unidentified ligand and is predicted to adopt an all beta structure. Features eleven transmembrane helices; High confidence in function and specificity. (486 aa)    
Predicted Functional Partners:
CAZ94656.1
Contains a prokaryotic lipoprotein signal peptide cleaved between the residues 18 and 19; Localized in the outer membrane; Hypothetical protein.
       0.633
CAZ95728.1
Sodium/hydrogen exchanger; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold, Contains twelve transmembrane helices; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family; Localized in the cytoplasmic membrane; Specificity unclear.
 
   
0.485
arsB
Arsenite resistance protein ArsB seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump. Belongs to the Sodium Bile acid symporter family; Contains ten transmembrane helices; Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
    0.466
arsC-2
Protein arsC reduces arsenate [As(V)] to arsenite [As(III)] (Arsenate reductase, EC 1.20.4.-) and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates (LMW protein-tyrosine-phosphatase, EC 3.1.3.48). Could switch between different functions in different circumstances. Localized in the cytoplasm; High confidence in function and specificity.
       0.451
CAZ94657.1
Conserved hypothetical membrane protein; Contains a N-terminal transmembrane helix; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
       0.446
kefC
The K(+)/H(+) antiporter KefC is a Glutathione-regulated potassium-efflux system protein responsible for glutathione-gated K+ efflux. Activation of KefC K+ efflux system only occurs in the presence of glutathione and a reactive electrophile such as methylglyoxal or N-ethylmaleimide. KefC is important for cell survival during exposure to toxic metabolites, possibly because they can release K+, allowing H+ uptake. H+ uptake (acidification of the cytoplasm) accompanying or following K+ efflux may serve as a further protective mechanism against electrophile toxicity; Contains 12 transmembr [...]
     
 0.406
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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