STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
idiAIsopentenyl-diphosphate Delta-isomerase is involved in isoprenoid biosynthesis. It catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl to its highly electrophilic allylic isomer, dimethylallyl diphosphate. Binds one magnesium as a cofactor when the substrate is also bound. Localized in the cytoplasm; High confidence in function and specificity. (239 aa)    
Predicted Functional Partners:
mvdA
Mevalonate diphosphate decarboxylase or diphosphomevalonate decarboxylase catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP), the last step in the synthesis of IPP in the mevalonate pathway. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes; Belongs to the GHMP kinase domain superfamily; Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.977
CAZ94094.1
Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.
  
  
 
0.926
idsA
Bifunctional short chain isoprenyl diphosphate synthase; IdsA is a bifunctional enzyme with dimethylallyltranstransferase and geranyltranstransferase activities. It is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopenteny [...]
  
 
 0.919
pts
6-Pyruvoyl tetrahydrobiopterin synthase is involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. It catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. It forms a homohexamer formed of two homotrimers in a head to head fashion. Localized in the cytoplasm; High confidence in function and specificity.
       0.820
CAZ94702.1
Thrombospondin type 3 repeats protein; The presence of two EF-hand calcium-binding domains, four putatif thrombospondin type 3 repeats and one calx-beta motif suggest that this sequence is a calcium binding protein. The calx-beta motif is present in the cytoplasmic domains of Calx Na-Ca exchangers; Contains a Galactose-binding domain; Signal peptide cleaved between the residues 34 and 35; Putatively localized in the outer membrane; Conserved hypothetical protein.
       0.746
pmiA
Mannose-6-phosphate isomerase or phosphomannose isomerase (PMI) is the enzyme that converts the mannose-6-phosphate to fructose-6-phosphate. Contains a phosphomannose isomerase type I domain; Binds 1 zinc ion per subunit; Belongs to the the cupin superfamily, mannose-6-phosphate isomerase type 1 family; Localized in the cytoplasm; High confidence in function and specificity.
       0.704
kmoA
Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid; Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
   
  
 0.579
CAZ94703.1
Conserved hypothetical protein; Contains a signal peptide cleaved between the residues 29 and 30; Localized in the periplasmic space.
       0.578
CAZ94704.1
Conserved protein containing five thrombospondin type 3 repeats (TSP3). TSP3 are calcium binding domains; Features an uncleaved signal peptide; Localized in the cytoplasmic meembrane; Conserved hypothetical protein.
       0.573
CAZ94698.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.568
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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