STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pglA6-Phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (237 aa)    
Predicted Functional Partners:
zwfA
Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
 
 0.999
gndA
6-Phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
 
 
 0.985
gntK2
Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.961
gntK1
Gluconokinase is involved in the gluconate catabolism pathway (Pentose phosphate pathway). It converts the D-gluconate to 6-phospho-D-gluconate; GntK adopts an alpha/beta fold, consisting of a central sheet of five parallel beta-strands flanked by alpha-helices; Belongs to the shikimate kinase family; Localized in the cytoplasm; High confidence in function and specificity.
   
 0.913
CAZ95093.1
Conserved protein distantly related to 6-phosphogluconolactonases; Localized in the cytoplasm; Function unclear.
     
 0.901
CAZ97731.1
3-carboxymuconate cyclase-like protein; Possible 3-carboxymuconate cyclase, which converts by isomerisation the 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate to 3-carboxy-cis,cis-muconate; Contains a signal peptide of lipoprotein cleaved between the residues 19 and 20; Belongs to the cycloisomerase 2 family; Localized in the cytoplasmic membrane; Family membership.
     
 0.901
nagA
N-acetylglucosamine-6-phosphate deacetylase, induced by N-acetylglucosamine, hydrolyses the N-acetyl-D-glucosamine 6-phosphate to D-glucosamine 6-phosphate in the N-acetylglucosamine utilization pathway; Belongs to the Amidohydrolase family; Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.788
glkA
Glucokinase is involved in the first step of the glycolysis (Embden-Meyerhof pathway). It phosphoryles the D-glucose to D-glucose 6-phosphate. This reaction consumes ATP, but it acts to keep the glucose concentration low, promoting continuous transport of glucose into the cell through the cytoplasmic membrane transporters; Localized in the cytoplasm; High confidence in function and specificity.
 
  
 0.503
dnaE1
The alpha subunit of DNA polymerase III is responsible of the polymerase activity; Contains a N-terminal exonuclease domain, a PHP domain (phosphoesterase) and a C-terminal OB module (oligonucleotide /oligosaccharide-binding fold) involved in the DNA binding; The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity; Localized in the cytoplasm; High confidence in function and specificity.
  
    0.472
dnaE2
The alpha subunit of DNA polymerase III is responsible of the polymerase activity; Contains a N-terminal PHP domain (phosphoesterase) and a C-terminal OB module (oligonucleotide/oligosaccharide-binding fold) involved in the DNA binding; The DNA polymerase III or replicase is responsible for most of the replicative synthesis in bacteria. It also exhibits a 3' to 5' exonuclease proofreading activity; Localized in the cytoplasm; High confidence in function and specificity.
   
    0.463
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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