Anthranilate synthase component II (glutamine amidotransferase); The anthranilate synthase catalyzes the formation of anthranilate from chorismate and L-glutamine, the first step in the biosynthesis of tryptophan. The enzyme is a Tetramer of two components I and two components II. Associated with the component I, the component II of the anthranilate synthase provides the glutamine amidotransferase activity (GATase, 2.4.2.-) that catalyses the removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen g [...]

Indole-3-glycerol phosphate synthase (IGPS) catalyzes the ring closure of 1-(2-carboxy-phenylamino)-1-deoxyribulose into indol-3-glycerol-phosphate, the fourth step in the biosynthesis of tryptophan; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the TrpC family.

The N-(5'-phosphoribosyl)anthranilate isomerase (PRAI) converts the N-(5-phospho-beta-D-ribosyl)anthranilate to 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate, the third step in the biosynthesis of tryptophan; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the TrpF family.

Anthranilate synthase component I-like protein; Enzyme that contains a C-terminal chorismate binding domain and belonging to the anthranilate synthase component I family; Localized in the cytoplasm; Family membership.

Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.

Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.

Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.

Homoserine O-acetyltransferase / Aspartokinase / Homoserine dehydrogenase; This enzyme is a modular protein with a homoserine O-acetyltransferase module (N-terminal) that catalyses the homoserine acetylation and belongs to the alpha/beta hydrolase fold family, an aspartate kinase module (central) that catalyzes the phosphorylation of aspartate and belongs to the amino acid kinase family and, in C- terminal part, a homoserine dehydrogenase module that catalyzes the NAD-dependent reduction of aspartate beta- semialdehyde into homoserine. This module is composed of a substrate-binding dom [...]

Histidine biosynthesis bifunctional protein HisIE; HisIE is a bifunctional enzyme containing a N-terminal phosphoribosyl-AMP cyclohydrolase (PRA-CH) domain and a C-terminal phosphoribosyl-ATP pyrophosphatase (PRA-PH) domain, catalyzing the third and second steps of the L-histidine biosynthetic pathway, respectively. PRA-CH catalyzes the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide. It requires Zn ions for activity. PRA-PH catalyzes the reaction: 1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)- [...]