STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdsAPhosphatidate cytidylyltransferase is essential for phospholipid biosynthesis. It catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate: CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. Features seven transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity; Belongs to the CDS family. (267 aa)    
Predicted Functional Partners:
uppS
Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
  
 0.942
pssA
Phosphatidylserine synthase; This enzyme, CDP-diacylglycerol--serine O-phosphatidyltransferase, is involved in phospholipid biosynthesis; Signal peptide cleaved between the residues 24 and 25, Contains six transmembrane segments; Localized in the cytoplasmic membrane; High confidence in function and specificity; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
  
 0.939
CAZ95847.1
Acyltransferase of unkown specificity; Contains a N-terminal transmembrane helix; Localized in the cytoplasmic membrane; Specificity unclear.
 
  
 0.921
dgkA
Diacylglycerol kinase recycles diacylglycerol produced during the turnover of membrane phospholipids. May play a role in adaptability to environmental stress conditions such as acid tolerance, elevated temperatures and high osmolarity. Features two transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
    
 0.917
plsC
1-acylglycerol-3-phosphate O-acyltransferase is involved in the phospholipid biosynthesis (second step). It converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position. The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate; Localized in the cytoplasm; High confidence in function and specificity.
    
 0.914
psd
Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
     
 0.865
CAZ94760.1
Conserved hypothetical protein; Localized in the cytoplasm.
       0.820
CAZ94763.1
Acyl-CoA binding protein (ACBP) is a small (~10 kDa) protein that binds medium- and long-chain acyl-CoA esters with high affinity, and may act as an intra- cellular carrier of acyl-CoA esters. It is a mainly-alpha protein, consisting of 5 short alpha-helices and 3 connecting beta-strands. Localized in the cytoplasm; Family membership.
 
     0.820
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
  
 0.730
rsfS
Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
     0.722
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.