STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (331 aa)    
Predicted Functional Partners:
kdtA
3-deoxy-D-manno-octulosonic-acid transferase, family GT30; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
 0.998
lpxB
Lipid-A-disaccharide synthase, family GT19; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
  
 0.993
kdsD
Arabinose 5-phosphate isomerase or Phosphoarabinoisomerase is involved in the lipopolysaccharide (LPS) biosynthesis; It catalyzes the interconversion of D-arabinose 5-phosphate and D-ribulose 5-phosphate; Contains a N-terminal SIS (Sugar ISomerase) domain that is a phosphosugar-binding domain and a C-terminal CBS (cystathionine-beta-synthase) domans; Belongs to the SIS family; Localized in the cytoplasm; High confidence in function and specificity.
 
   
 0.844
lpxA
Acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
   
 0.842
kdsB
The 3-Deoxy-manno-octulosonate cytidylyltransferase, also known as CMP-KDO synthetase, activates KDO (a 8-carbon sugar) required for incorporation into bacterial lipopolysaccharide in Gram- negative bacteria; It binds one magnesium ion as cofactor; Localized in the cytoplasm; High confidence in function and specificity; Belongs to the KdsB family.
 
   
 0.842
kdsA
The 3-Deoxy-8-phosphooctulonate synthase is involved in the biosynthesis of KDO-8P, a precursor of lipid A; It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate, the first step in the biosynthesis of 3-deoxy-D-manno- octulosonate, part of the oligosaccharide core of lipopolysaccharide; It forms a homotrimer; Belongs to the DAHP synthetase I family; Localized in the cytoplasm; High confidence in function and specificity.
 
   
 0.839
htrB
Lipid A biosynthesis lauroyl acyltransferase is involved in lipopolysaccharide biosynthesis. It transfers myristate or laurate, activated on ACP, to the lipid A moiety of (KDO)2-(lauroyl)-lipid IVA during lipopolysaccharide core biosynthesis. Features a N-terminal transmembrane helix. Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
  
 0.829
lpxD2
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
   
 0.821
lpxD1
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; LpxD catalyzes the third step of lipid A biosynthesis; LpxD features eight tandem repeats of a [LIV]-G-X(4) hexapeptide, which has been shown to fold as a left-handed parallel beta helix; Localized in the cytoplasm; High confidence in function and specificity.
 
   
 0.810
lpxC/fabZ4
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily.
 
   
 0.783
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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