N-formylkynurenine (aryl-) formamidase is an enzyme involved in the tryptophan metabolism. It hydrolyses the N-formyl-L-kynurenine to L-kynurenine and formate; belongs to the cyclase family; Localized in the cytoplasm; High confidence in function and specificity.

3-Hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.

Tryptophan 2,3-dioxygenase is Involved in L-kynurenine metabolism from L-tryptophan,incorporating oxygen into the indole moiety of tryptophan. It has a broad specificity towards tryptamine and derivatives including D-and L-tryptophan, 5-hydroxytryptophan and serotonin; This enzyme forms a tetramer and binds 2 hemes per subunit; Localized in the cytoplasm; High confidence in function and specificity.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase catalyzes the reversible conversion of mevalonate into 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA), using coenzyme A and NAD(P) as cofactors. In Archeae, NADP-depedent HMG-CoA reductase is involved in the biosynthesis of the isoprenoids side chains of lipids. Some bacteria, such as Pseudomonas mevalonii, use an NAD-dependent HMG-CoA reductase to deacetylate mevalonate into 3-hydroxy-3-methylglutaryl-CoA. These bacteria can use mevalonate as sole carbon source. Localized in the cytoplasm; High confidence in function and specificity.

Tryptophan 2,3-dioxygenase is Involved in L-kynurenine metabolism from L-tryptophan,incorporating oxygen into the indole moiety of tryptophan. It has a broad specificity towards tryptamine and derivatives including D-and L-tryptophan, 5-hydroxytryptophan and serotonin; This enzyme forms a tetramer and binds 2 hemes per subunit; Localized in the cytoplasm; High confidence in function and specificity.

Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics; P450 enzymes usually act as terminal oxidases in multicomponent electron transfer chains, called P450-containing monooxygenase systems; Acts with the ferredoxin and the ferredoxin reductase; Localized in the cytoplasm; Specificity unclear.

Conserved hypothetical protein; Localized in the cytoplasm.

Members of the Nudix hydrolase family catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. They require Mg2+ or Mn2+, for their activity. Substrates include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance & \house- cleaning\ enzymes; Belong to the Nudix hydrolase superfamily; Localized in the cytoplasm; Family membership.