STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trkHTrkH is a low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity. Features ten transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity. (485 aa)    
Predicted Functional Partners:
trkA
TrkA is part of the constitutive potassium transport systems trkG and trkH. May regulate the transport activity of trkG and trkH systems. Binds to NAD+ and NADH. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.974
CAZ95728.1
Sodium/hydrogen exchanger; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold, Contains twelve transmembrane helices; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family; Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.917
CAZ95729.1
Sodium/hydrogen exchanger; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. This integral membrane protein also contains a C-terminal TrkA- N domain which binds NAD and adopts a Rossmann fold; Contains twelve transmembrane helices; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter family; Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.896
CAZ98890.1
Conserved ion channel belonging to the sodium, Potassium, Calcium ion channel family. Its specificity is unknown. Features five transmembrane helices. Localized in the cytoplasmic membrane; Specificity unclear.
  
 
 0.604
mthK
This channel transports potassium ion in response to intracellular calcium ion binding. Eight RCK domains (regulators of K+ conductance) form a gating ring at the intracellular membrane surface. The gating ring uses the free energy of Ca2+ binding in a simple manner to perform mechanical work to open the pore. This channel is a homotetramer and the monomer subunit features three transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
  
 
 0.604
menG/ubiE
Menaquinone/ubiquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
       0.485
kefC
The K(+)/H(+) antiporter KefC is a Glutathione-regulated potassium-efflux system protein responsible for glutathione-gated K+ efflux. Activation of KefC K+ efflux system only occurs in the presence of glutathione and a reactive electrophile such as methylglyoxal or N-ethylmaleimide. KefC is important for cell survival during exposure to toxic metabolites, possibly because they can release K+, allowing H+ uptake. H+ uptake (acidification of the cytoplasm) accompanying or following K+ efflux may serve as a further protective mechanism against electrophile toxicity; Contains 12 transmembr [...]
  
 
 0.424
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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