STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ziaAZiaA is a P-type ATPase responsible for zinc efflux using ATP hydrolysis for energy. ZiaA controls zinc homeostasis. Belongs to the cation transport P-type ATPase family. Features six transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity. (665 aa)    
Predicted Functional Partners:
CAZ97328.1
Transcriptional regulator featuring a helix-turn-helix DNA binding motif belonging to the Fur family. This family includes metal ion uptake regulator, that bind to the operator DNA and controls transcription of metal ion-responsive genes. Localized in the cytoplasm; Specificity unclear.
 
   
 0.758
actP
ActP is a P-type ATPase responsible for copper efflux using ATP hydrolysis for energy. ActP controls copper homeostasis. Belongs to the cation transport P-type ATPase family. Features eight transmembrane helices. Localized in the cytoplasmic membrane; High confidence in function and specificity.
 
 
0.695
CAZ94847.1
Conserved hypothetical membrane protein; Contains one transmembrane helix; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
 
   
 0.679
CAZ95221.1
Metal transport-related protein; Seems to contain a Heavy metal associated domain (HMA domain) being involved in bacterial resistance to toxic metals; Signal peptide cleaved between the residues 19 and 20; Exported in the periplasmic space; Conserved hypothetical protein.
  
 
 0.609
CAZ94368.1
This protein belongs to the Heavy metal transport protein family. The Heavy-Metal-Associated (HMA) domain contains two conserved cysteines that are probably involved in metal binding. Its structure comprises our- stranded antiparallel beta-sheet and two alpha helices packed in an alpha-beta sandwich fold. Somes of these HMA proteins are involved in bacterial resistance to toxic metals, such as lead and cadmium. Localized in the cytoplasm; Specificity unclear.
  
 
 0.603
CAZ94845.1
TonB-dependent Receptor; Protein localized in the outer membrane involved in uptake of macromolecules that are too large to diffuse via the outer membrane porins channels or are encountered at very low concentrations; Contains a carboxypeptidase regulatory domain (29-114) and the Plug module (130-226) acting as a channel gate; The signal peptide is cleaved between the residues 24 and 25; Family membership.
       0.490
CAZ94844.1
Conserved hypothetical membrane protein; Contains three transmembrane helices; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
       0.454
CAZ95705.1
ArsR-type transcriptional regulator; This transcription regulatory protein binds DNA via a helix-turn-helix (HTH) motif. The ArsR family includes several proteins that appear to dissociate from DNA in the presence of metal ions. Metal ion binding would induce a conformational change that would prevent the protein from binding DNA. This protein adopts a fold of five alpha-helices and a pair of antiparallel beta-strands. Most ArsR-like metalloregulators form homodimers. Localized in the cytoplasm; Specificity unclear.
 
  
 0.408
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.