STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurrence
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[Homology]
Score
manCMannose-1-phosphate guanylyltransferase, also known as GDP-mannose pyrophosphorylase, is Involved in the biosynthesis of exopolysaccharides. It catalyzes the reaction: GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose. Localized in the cytoplasm; High confidence in function and specificity. (360 aa)    
Predicted Functional Partners:
gmdA
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
 
 
 0.946
algC
Phosphomannomutase/phosphoglucomutase; AlgC catalyzes the interconversion between mannose-6-phosphate and alpha-mannose-1-phosphate. It has also a phosphoglucomutase activity interconverting glucose-6-phosphate and alpha-glucose-1-phosphate. Likely involved in EPS/LPS biosynthesis. Binds one magnesium as cofactor. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.945
algD
GDP-mannose 6-dehydrogenase catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid. In Pseudomonas aeruginosa, this activated sugar is the precursor for alginate polymerization. AlgD belongs to the UDP-glucose/GDP- mannose dehydrogenase family, a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate. Localized in the cytoplasm; High confidence in function and specificity.
 
 
 0.941
pmiA
Mannose-6-phosphate isomerase or phosphomannose isomerase (PMI) is the enzyme that converts the mannose-6-phosphate to fructose-6-phosphate. Contains a phosphomannose isomerase type I domain; Binds 1 zinc ion per subunit; Belongs to the the cupin superfamily, mannose-6-phosphate isomerase type 1 family; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.900
CAZ94947.1
Protein belonging to the DUF389 family; Contains six transmembrane helices; Localized in the cytoplasmic membrane; Conserved hypothetical protein.
       0.820
CAZ96045.1
Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains five transmembrane helices. Localized in the cytoplasmic membrane; Function unclear.
  
  
 0.816
CAZ94949.1
SprT family protein; Conserved protein belonging to a family including SprT, a regulator of bolA gene in stationary phase. Displays a conserved HExxH motif reminiscent of the metallopeptidase zinc binding signature. Localized in the cytoplasm; Family membership.
       0.636
capD
CapD is involved in EPS/LPS biosynthesis. Its exact function is unknown; Contains five transmembrane helices; Localized in the cytoplasmic membrane; Function unclear.
  
  
 0.519
wzcA
Tyrosine-protein kinase; May be involved in the production and the transport of exopolysaccharides; Contains a N-terminal transmembrane segment; Belongs to the etk/wzc family; Localized in the cytoplasmic membrane; Specificity unclear.
 
  
 0.495
CAZ95164.1
Conserved protein involved in exopolysaccharide biosynthesis. Its exact function is unknown. Contains five transmembrane helices. Localized in the cytoplasmic membrane; Specificity unclear.
  
  
 0.455
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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