STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
fadDLong-chain-fatty-acid-CoA ligase; FadD catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It forms a homodimer. Localized in the cytoplasm; High confidence in function and specificity. (591 aa)    
Predicted Functional Partners:
fadN
3-Hydroxyl-CoA dehydrogenase / Enoyl-CoA hydratase; Modular protein containing a N-terminal 3-Hydroxyl-CoA dehydrogenase domain and a C-terminal Enoyl-CoA hydratase domain. In Bacillus subtilis, this protein was formerly known as YusL, and has been renamed FadN by Matsuoka et al (JBC, 2007). FadN is involved in fatty acid degradation. 3-Hydroxyl-CoA dehydrogenase catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. It uses NAD as cofactor. Enoyl-CoA hydratase catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. Localized in the cytoplasm; High confidence in [...]
 
 
 0.782
fadE
Acyl-CoA dehydrogenase is involved in fatty acid degradation. It catalyzes the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3- enoyl CoA-products with concommitant reduction of enzyme- bound FAD. In Bacillus subtilis, this protein, formerly known as yusJ protein, has been renamed FadE by Matsuoka et al (JBC, 2007). Localized in the cytoplasm; Specificity unclear.
 
 0.771
CAZ97540.1
Conserved hypothetical protein; Localized in the cytoplasm.
    
 0.713
CAZ94457.1
Type I polyketide synthases are modular enzymes involved in the synthesis of various polyketides. This enzyme encompasses five modules: beta-ketoacyl synthase (KS), acyltransferase (AC), dehydratase (DH), enoyl reductase (ER) and acyl carrier protein (ACP). This modular enzyme is homologous to mycocerosic acid synthase (EC 2.3.1.111). Binds 1 phosphopantetheine group covalently. Localized in the cytoplasmic membrane; Specificity unclear.
 
 
 0.692
acxA
Acyl-coA oxidase, with FAD cofactor, converts acyl-CoA into trans-2-enoyl-CoA; Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18); Family membership.
 
 0.689
gcdH
Glutaryl-CoA dehydrogenase catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism; Uses FAD as prosthetic group; Belongs to the acyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.683
CAZ94724.1
Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. Reoxidation of the flavin involves transfer of electrons to ETF (electron transfering flavoprotein). These enzymes are homodimers containing one molecule of FAD; Localized in the cytoplasm; Specificity unclear.
  
 0.642
bcdA
Butyryl-CoA dehydrogenase converts the Butanoyl-CoA to 2-butenoyl-CoA. It uses electron transfer flavoprotein (FAD) as its electron acceptor; Localized in the cytoplasm; High confidence in function and specificity.
  
 0.642
gmkA
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
    
  0.638
rplE
Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
    
 
 0.523
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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