STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fadN3-Hydroxyl-CoA dehydrogenase / Enoyl-CoA hydratase; Modular protein containing a N-terminal 3-Hydroxyl-CoA dehydrogenase domain and a C-terminal Enoyl-CoA hydratase domain. In Bacillus subtilis, this protein was formerly known as YusL, and has been renamed FadN by Matsuoka et al (JBC, 2007). FadN is involved in fatty acid degradation. 3-Hydroxyl-CoA dehydrogenase catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA. It uses NAD as cofactor. Enoyl-CoA hydratase catalyzes the hydratation of 2-trans-enoyl-CoA into 3-hydroxyacyl-CoA. Localized in the cytoplasm; High confidence in [...] (801 aa)    
Predicted Functional Partners:
thlA
Acetyl-CoA acetyltransferase is specific for the thiolysis of acetoacetyl-CoA and involved in biosynthetic pathways such as poly beta-hydroxybutyrate synthesis or mevalonate biogenesis. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.
 
 0.999
fadA
3-Ketoacyl-CoA thiolase, also known as acetyl-CoA C-acyltransferase, has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation. It catalyzes the reaction: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. Localized in the cytoplasm; High confidence in function and specificity; Belongs to the thiolase-like superfamily. Thiolase family.
 
 0.999
fadE
Acyl-CoA dehydrogenase is involved in fatty acid degradation. It catalyzes the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3- enoyl CoA-products with concommitant reduction of enzyme- bound FAD. In Bacillus subtilis, this protein, formerly known as yusJ protein, has been renamed FadE by Matsuoka et al (JBC, 2007). Localized in the cytoplasm; Specificity unclear.
 
 0.986
crtA
3-hydroxybutyryl-CoA dehydratase; Enzyme, also called crotonase, that participates to the fatty acid metabolism in the Butyrate/butanol-producing pathway; High confidence in function and specificity; Belongs to the enoyl-CoA hydratase/isomerase family.
 0.977
scoB
3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoB is the subunit B. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm; High confidence in function and specificity.
  
 0.952
scoA
3-Oxoacid CoA-transferase catalyzes the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA. It is an homodimer of a subunit A and a subunit B. ScoA is the subunit A. The transfer of CoA from one substrate to another occurs via a ping pong mechanism which involves the formation of thioester bond between CoA and a conserved glutamate residue at the active site of the enzyme. Localized in the cytoplasm; High confidence in function and specificity.
  
 
 0.946
hbdA
The 3-Hydroxybutyryl-CoA dehydrogenase is involved in butyrate/butanol-producing pathway. It converts the (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 
0.939
bcdA
Butyryl-CoA dehydrogenase converts the Butanoyl-CoA to 2-butenoyl-CoA. It uses electron transfer flavoprotein (FAD) as its electron acceptor; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.936
gcdH
Glutaryl-CoA dehydrogenase catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism; Uses FAD as prosthetic group; Belongs to the acyl-CoA dehydrogenase family; Localized in the cytoplasm; High confidence in function and specificity.
 
 0.930
acxA
Acyl-coA oxidase, with FAD cofactor, converts acyl-CoA into trans-2-enoyl-CoA; Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18); Family membership.
  
 0.917
Your Current Organism:
Zobellia galactanivorans
NCBI taxonomy Id: 63186
Other names: CCUG 47099, CIP 106680, Cytophaga drobachiensis, DSM 12802, Flavobacterium droebachense, Pseudomonas droebachense, Z. galactanivorans, Zobellia galactanivorans corrig. Barbeyron et al. 2001, Zobellia galactanovorans, strain Dsij
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