STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rthUndecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa)    
Predicted Functional Partners:
cds
Similar to Escherichia coli phosphatidate cytidylyltransferase cdsA or cds SW:CDSA_ECOLI (P06466) (249 aa) fasta scores: E(): 0, 75.2% id in 246 aa; Belongs to the CDS family.
 
  
 0.986
ispA-2
Geranyltranstransferase; Similar to Escherichia coli geranyltranstransferase IspA SW:ISPA_ECOLI (P22939) (299 aa) fasta scores: E(): 0,72.5% id in 298 aa, and to Vibrio cholerae geranyltranstransferase Vc0890 TR:Q9KTL2 (EMBL:AE004173) (294 aa) fasta scores: E(): 0, 64.1% id in 295 aa; Belongs to the FPP/GGPP synthase family.
 
 
 0.981
cel
Similar to Escherichia coli octaprenyl-diphosphate synthase IspB or Cel SW:ISPB_ECOLI (P19641) (323 aa) fasta scores: E(): 0, 79.4% id in 321 aa, and to Vibrio cholerae octaprenyl-diphosphate synthase Vc0434 TR:Q9KUT1 (EMBL:AE004131) (348 aa) fasta scores: E(): 0, 72.9% id in 321 aa; Belongs to the FPP/GGPP synthase family.
 
 
 0.976
b0173
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP).
  
  
 0.957
rseP
Putative membrane protein; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA (By similarity); Belongs to the peptidase M50B family.
  
  
 0.952
bacA
Putative bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
   
 
 0.951
YPO1324
Putative permease; Similar to Bacillus licheniformis bacitracin transport permease protein BcrC SW:BCRC_BACLI (P42334) (203 aa) fasta scores: E(): 1.4e-07, 30.0% id in 170 aa, and to Salmonella typhimurium putative permease Mig-13 TR:O30906 (EMBL:AF020809) (202 aa) fasta scores: E(): 0, 57.9% id in 197 aa.
  
 
 0.946
b0172
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
  
  
 0.920
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
 
  
 0.869
drpA
prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]
  
    0.860
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.