STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
queCConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (232 aa)    
Predicted Functional Partners:
queE
Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.996
queF
Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
 
 
 0.991
ygcM
Similar to Escherichia coli putative 6-pyruvoyl tetrahydrobiopterin synthase YgcM SW:PTPS_ECOLI (Q46903) (121 aa) fasta scores: E(): 0, 83.2% id in 119 aa, and to Vibrio cholerae putative 6-pyruvoyl tetrahydrobiopterin synthase Vc1299 TR:Q9KSF7 (EMBL:AE004209) (122 aa) fasta scores: E(): 0, 76.5% id in 119 aa.
 
  
 0.954
nrdG
Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
  
 
 0.855
YPO3149
Similar to Escherichia coli hypothetical protein YbaE SW:YBAE_ECOLI (P46890) (566 aa) fasta scores: E(): 0,46.5% id in 563 aa, and to Vibrio cholerae hypothetical protein VCA0578 TR:Q9KM11 (EMBL:AE004388) (565 aa) fasta scores: E(): 0, 25.9% id in 580 aa.
  
    0.493
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
    
  0.476
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
   
 0.466
folE
Similar to Escherichia coli GTP cyclohydrolase I SW:GCH1_ECOLI (P27511) (221 aa) fasta scores: E(): 0, 90.0% id in 219 aa, and to Vibrio cholerae GTP cyclohydrolase Vca0616 TR:Q9KLX5 (EMBL:AE004391) (230 aa) fasta scores: E(): 0, 70.2% id in 218 aa.
  
  
 0.449
YPO0370
Putative N-acetylmuramoyl-L-alanine amidase-family protein; Similar to Escherichia coli cell wall hydrolase: N-acetylmuramoyl-L-alanine amidase amiB precursor SW:AMIB_ECOLI (P26365) (445 aa) fasta scores: E(): 4e-86,61.247% id in 449 aa. Also similar to Vibrio cholerae N-acetylmuramoyl-L-alanine amidase vc0344 TR:Q9KV14 (EMBL:AE004123) (581 aa) fasta scores: E(): 2.5e-41,37.605% id in 593 aa. Note that like the Vibrio cholerae hit the Y. pestis predicted product also possesses an additional LysM domain which may be involved in peptidoglycan binding.
     
 0.429
glmS
Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
  0.422
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.