Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ06245.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: tpd:Teth39_1970 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (332 aa)    
Predicted Functional Partners:
ADQ08151.1
KEGG: csc:Csac_1304 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein.
  
  
 
0.917
ADQ06373.1
KEGG: ate:Athe_2125 D-3-phosphoglycerate dehydrogenase; TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; amino acid-binding ACT domain protein.
  
  
 
0.916
gpmI
Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
   
 
 0.901
ADQ06246.1
Hypothetical protein.
       0.678
ADQ06244.1
PFAM: PfkB domain protein; KEGG: tpd:Teth39_1972 ribokinase-like domain-containing protein; Belongs to the carbohydrate kinase PfkB family.
 
   
 0.628
ADQ06247.1
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pmo:Pmob_0444 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 
 0.605
ADQ08001.1
PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: ate:Athe_0325 homocysteine S-methyltransferase.
   
 
 0.587
pgk
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
 
 
 0.514
ADQ06243.1
KEGG: tpd:Teth39_1973 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase.
       0.462
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.455
Your Current Organism:
Caldicellulosiruptor hydrothermalis
NCBI taxonomy Id: 632292
Other names: C. hydrothermalis 108, Caldicellulosiruptor hydrothermalis 108, Caldicellulosiruptor hydrothermalis DSM 18901, Caldicellulosiruptor hydrothermalis str. 108, Caldicellulosiruptor hydrothermalis strain 108
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