Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ06247.1PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pmo:Pmob_0444 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (272 aa)    
Predicted Functional Partners:
ADQ06246.1
Hypothetical protein.
       0.658
ADQ06245.1
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; KEGG: tpd:Teth39_1970 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.
  
 
 0.605
uxaC
KEGG: ate:Athe_1402 glucuronate isomerase; PFAM: Glucuronate isomerase.
 
  
 0.600
ADQ06244.1
PFAM: PfkB domain protein; KEGG: tpd:Teth39_1972 ribokinase-like domain-containing protein; Belongs to the carbohydrate kinase PfkB family.
 
 
 
 0.491
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.459
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.443
ADQ05894.1
PFAM: PfkB domain protein; KEGG: csc:Csac_2720 ribokinase-like domain-containing protein.
 
 
 
 0.436
ADQ06248.1
KEGG: dtu:Dtur_1774 TRAP dicarboxylate transporter-DctP subunit; TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: Extracellular solute-binding protein, family 7.
     
 0.418
ADQ06251.1
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: dtu:Dtur_1771 short-chain dehydrogenase/reductase SDR.
 
    
0.418
ADQ06243.1
KEGG: tpd:Teth39_1973 5-carboxymethyl-2-hydroxymuconate delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase.
  
 
 0.406
Your Current Organism:
Caldicellulosiruptor hydrothermalis
NCBI taxonomy Id: 632292
Other names: C. hydrothermalis 108, Caldicellulosiruptor hydrothermalis 108, Caldicellulosiruptor hydrothermalis DSM 18901, Caldicellulosiruptor hydrothermalis str. 108, Caldicellulosiruptor hydrothermalis strain 108
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