Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ06420.1PFAM: PfkB domain protein; KEGG: ate:Athe_2118 PfkB domain protein. (316 aa)    
Predicted Functional Partners:
ADQ07892.1
Glycosyl hydrolase family 32 domain protein; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family.
 
 0.959
ADQ08172.1
KEGG: ate:Athe_0149 PTS system, fructose subfamily, IIC subunit; TIGRFAM: PTS system, fructose subfamily, IIC subunit; PTS system, fructose-specific, IIB subunnit; PFAM: phosphotransferase system EIIC.
     
 0.935
pfp
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
  
 0.925
ADQ06298.1
PFAM: Alcohol dehydrogenase GroES domain protein; Alcohol dehydrogenase zinc-binding domain protein; KEGG: ate:Athe_2206 alcohol dehydrogenase GroES domain protein.
 
 
 0.918
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
   
 0.913
ADQ07747.1
TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; KEGG: ate:Athe_0619 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; sugar isomerase (SIS).
  
 
 0.912
ADQ07681.1
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: ate:Athe_0698 short-chain dehydrogenase/reductase SDR.
   
 0.910
xylA
TIGRFAM: xylose isomerase; KEGG: ate:Athe_0603 xylose isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the xylose isomerase family.
     
 0.906
ADQ06378.1
PFAM: PfkB domain protein; KEGG: csc:Csac_1312 ribokinase-like domain-containing protein.
  
  
 
0.902
ADQ05843.1
KEGG: dtu:Dtur_1620 glutamine--fructose-6-phosphate transaminase (isomerizing); PFAM: sugar isomerase (SIS).
     
 0.901
Your Current Organism:
Caldicellulosiruptor hydrothermalis
NCBI taxonomy Id: 632292
Other names: C. hydrothermalis 108, Caldicellulosiruptor hydrothermalis 108, Caldicellulosiruptor hydrothermalis DSM 18901, Caldicellulosiruptor hydrothermalis str. 108, Caldicellulosiruptor hydrothermalis strain 108
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