STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa)    
Predicted Functional Partners:
ADQ07675.1
PFAM: Transketolase central region; dehydrogenase E1 component; Transketolase domain protein; KEGG: ate:Athe_0704 transketolase central region.
  
 0.976
ADQ07734.1
TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; KEGG: ate:Athe_0632 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase.
    
 0.949
glmU
UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
 
  
 0.944
ADQ05956.1
PFAM: Transketolase domain protein; Transketolase central region; KEGG: ate:Athe_2328 transketolase domain protein.
   
 
 0.943
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.930
ADQ07101.1
PFAM: NUDIX hydrolase; KEGG: ate:Athe_1342 NUDIX hydrolase.
  
 
 0.914
deoB
Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
     
 0.911
ADQ06433.1
PFAM: Transketolase domain protein; KEGG: ate:Athe_2060 transketolase domain protein.
    
 0.909
ADQ05801.1
PFAM: NUDIX hydrolase; KEGG: csc:Csac_2565 NUDIX hydrolase.
    
 0.908
ADQ06434.1
PFAM: Transketolase central region; Transketolase domain protein; KEGG: csc:Csac_1352 transketolase, central region.
    
  0.906
Your Current Organism:
Caldicellulosiruptor hydrothermalis
NCBI taxonomy Id: 632292
Other names: C. hydrothermalis 108, Caldicellulosiruptor hydrothermalis 108, Caldicellulosiruptor hydrothermalis DSM 18901, Caldicellulosiruptor hydrothermalis str. 108, Caldicellulosiruptor hydrothermalis strain 108
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