Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ08001.1PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: ate:Athe_0325 homocysteine S-methyltransferase. (605 aa)    
Predicted Functional Partners:
ADQ06038.1
5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.998
ADQ07651.1
PFAM: dihydropteroate synthase DHPS; KEGG: ate:Athe_0749 dihydropteroate synthase DhpS.
  
 0.998
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.983
ADQ06016.1
PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; KEGG: ate:Athe_2582 methionine synthase.
  
 0.981
fhs
KEGG: ate:Athe_2208 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS.
  
 0.969
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.965
ADQ06552.1
PFAM: homoserine dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: ate:Athe_1959 homoserine dehydrogenase.
  
 
 0.963
ADQ07259.1
PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: csc:Csac_1639 O-acetylhomoserine aminocarboxypropyltransferase.
  
 
 0.960
ADQ07325.1
TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; KEGG: ate:Athe_1124 O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein.
  
 
 0.960
folD
Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.960
Your Current Organism:
Caldicellulosiruptor hydrothermalis
NCBI taxonomy Id: 632292
Other names: C. hydrothermalis 108, Caldicellulosiruptor hydrothermalis 108, Caldicellulosiruptor hydrothermalis DSM 18901, Caldicellulosiruptor hydrothermalis str. 108, Caldicellulosiruptor hydrothermalis strain 108
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