Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADQ03650.1KEGG: ate:Athe_0063 hypothetical protein. (235 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.595
ADQ03792.1
PFAM: Conserved hypothetical protein CHP02678; KEGG: ate:Athe_0248 hypothetical protein.
 
 
   0.562
scpA
Chromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
 
 0.562
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.558
ADQ03649.1
TIGRFAM: Undecaprenyl-phosphate glucose phosphotransferase; exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; KEGG: csc:Csac_2566 undecaprenyl-phosphate galactose phosphotransferase; PFAM: sugar transferase.
       0.549
ADQ03654.1
KEGG: ate:Athe_0077 S-layer domain protein; PFAM: transglutaminase domain-containing protein; S-layer domain-containing protein; Ig domain protein group 1 domain protein; SMART: transglutaminase domain-containing protein.
 
 
 
 0.520
ADQ03646.1
PFAM: glycosyl transferase group 1; KEGG: csc:Csac_2570 glycosyl transferase, group 1.
  
   0.501
ADQ03647.1
PFAM: glycosyl transferase group 1; KEGG: csc:Csac_2569 glycosyl transferase, group 1.
  
   0.501
ADQ03648.1
PFAM: glycosyl transferase group 1; KEGG: csc:Csac_2568 glycosyl transferase, group 1.
  
   0.501
ADQ04415.1
PFAM: histone deacetylase superfamily; KEGG: ate:Athe_1031 histone deacetylase superfamily.
    
 0.496
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.