Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ADQ03719.1KEGG: csc:Csac_2420 AbrB family transcriptional regulator; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain-containing protein. (80 aa)    
Predicted Functional Partners:
ADQ04691.1
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.728
ADQ04105.1
KEGG: ate:Athe_0646 hypothetical protein.
  
   
 0.674
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.634
ADQ05675.1
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.608
ADQ05764.1
PFAM: GerA spore germination protein; KEGG: ate:Athe_2765 GerA spore germination protein.
  
   
 0.574
ADQ04346.1
TIGRFAM: stage III sporulation protein AC; KEGG: ate:Athe_0992 stage III sporulation protein AC.
  
   
 0.557
ADQ05078.1
KEGG: ate:Athe_1789 stage II sporulation protein P; TIGRFAM: stage II sporulation protein P; PFAM: Stage II sporulation P family protein.
  
   
 0.514
ADQ05225.1
PFAM: GerA spore germination protein; KEGG: ate:Athe_1956 GerA spore germination protein.
  
   
 0.511
ADQ05264.1
KEGG: ate:Athe_2041 RNA polymerase, sigma-24 subunit, ECF subfamily; TIGRFAM: RNA polymerase sigma-H factor; RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 2 domain protein; Sigma-70 region 4 type 2.
  
   
 0.509
nnrE
Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...]
  
    0.508
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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