STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCKEGG: ate:Athe_0373 thiamine biosynthesis protein ThiC; TIGRFAM: thiamine biosynthesis protein ThiC; PFAM: thiamine biosynthesis protein ThiC. (422 aa)    
Predicted Functional Partners:
ADQ03847.1
KEGG: ate:Athe_0381 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 
 0.997
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.987
ADQ03842.1
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.982
ADQ03843.1
PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; KEGG: csc:Csac_0252 thiamine biosynthesis protein ThiH.
 
  
 0.969
ADQ03715.1
KEGG: ate:Athe_0169 biotin and thiamin synthesis associated; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
  
  
 0.847
ADQ03841.1
KEGG: ate:Athe_0368 thiamine biosynthesis protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein.
  
  
 0.830
ADQ03844.1
KEGG: ate:Athe_0371 thiamine biosynthesis protein ThiF; TIGRFAM: thiamine biosynthesis protein ThiF; PFAM: UBA/THIF-type NAD/FAD binding protein.
       0.830
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; KEGG: ate:Athe_1447 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein; AIR synthase related protein.
     
 0.806
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
ADQ04246.1
PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: ate:Athe_0823 UBA/ThiF-type NAD/FAD binding protein.
  
  
 0.775
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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