Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ03966.1KEGG: ate:Athe_0525 isocitrate dehydrogenase (NAD(+)); PFAM: isocitrate/isopropylmalate dehydrogenase. (335 aa)    
Predicted Functional Partners:
ADQ03965.1
KEGG: ate:Athe_0524 aconitate hydratase; TIGRFAM: aconitate hydratase; homoaconitate hydratase family protein; PFAM: aconitate hydratase domain-containing protein.
 
 0.910
leuD
3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.
  
 0.910
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 
 0.906
ADQ04482.1
PFAM: thiamine pyrophosphate TPP-binding domain-containing protein; KEGG: ate:Athe_1097 thiamine pyrophosphate protein domain protein TPP-binding.
   
 
 0.903
ADQ04480.1
KEGG: ate:Athe_1095 4Fe-4S ferredoxin iron-sulfur binding domain protein.
     
 0.902
ADQ04481.1
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: ate:Athe_1096 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
     
 0.901
ADQ04483.1
PFAM: Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; KEGG: ate:Athe_1098 pyruvate ferredoxin/flavodoxin oxidoreductase.
     
  0.900
ADQ04509.1
PFAM: aminotransferase class I and II; KEGG: ate:Athe_1128 aminotransferase class I and II.
  
 0.835
argH
KEGG: ate:Athe_1248 argininosuccinate lyase; TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase.
  
 
 0.829
ADQ04103.1
KEGG: ate:Athe_0644 glutamate synthase (NADPH), homotetrameric; TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase.
    
 0.815
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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