Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ04376.1Transcriptional regulator, XRE family; KEGG: afl:Aflv_0637 SOS-response transcriptional repressor LexA (HTH, RecA-mediated autopeptidase); PFAM: helix-turn-helix domain protein; Peptidase S24/S26A/S26B, conserved region; SMART: helix-turn-helix domain protein. (230 aa)    
Predicted Functional Partners:
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.945
dinB
DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.782
ADQ04375.1
PFAM: restriction endonuclease; KEGG: cph:Cpha266_1614 restriction endonuclease.
  
    0.719
ADQ04689.1
DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.572
ADQ04377.1
Helix-turn-helix domain protein; KEGG: chy:CHY_1696 prophage LambdaCh01, PBSX family transcriptional regulator; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein.
       0.525
ADQ04374.1
KEGG: btl:BALH_0255 hypothetical protein.
       0.500
ADQ04379.1
Prophage antirepressor; PFAM: BRO domain protein; phage antirepressor protein; KEGG: gka:GK0519 phage associated-antirepressor.
  
  
 0.489
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
  
 0.477
cinA
KEGG: ate:Athe_0985 competence/damage-inducible protein CinA; TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; Belongs to the CinA family.
     
 0.464
ADQ04378.1
Helix-turn-helix domain protein; KEGG: chy:CHY_1694 putative prophage LambdaCh01, transcriptional regulator; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein.
     
 0.455
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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