| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADQ03968.1 | ADQ04193.1 | Calow_0382 | Calow_0617 | PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Mur ligase middle domain protein; KEGG: ate:Athe_0527 Mur ligase middle domain protein. | SMART: PASTA domain containing protein; TIGRFAM: stage V sporulation protein D; KEGG: ate:Athe_0772 stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein. | 0.836 |
| ADQ03968.1 | murJ-2 | Calow_0382 | Calow_1249 | PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Mur ligase middle domain protein; KEGG: ate:Athe_0527 Mur ligase middle domain protein. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.565 |
| ADQ04193.1 | ADQ03968.1 | Calow_0617 | Calow_0382 | SMART: PASTA domain containing protein; TIGRFAM: stage V sporulation protein D; KEGG: ate:Athe_0772 stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein. | PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Mur ligase middle domain protein; KEGG: ate:Athe_0527 Mur ligase middle domain protein. | 0.836 |
| ADQ04193.1 | murJ-2 | Calow_0617 | Calow_1249 | SMART: PASTA domain containing protein; TIGRFAM: stage V sporulation protein D; KEGG: ate:Athe_0772 stage V sporulation protein D; PFAM: penicillin-binding protein transpeptidase; Penicillin-binding protein dimerisation domain; PASTA domain containing protein. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.462 |
| ADQ04440.1 | murJ-2 | Calow_0872 | Calow_1249 | KEGG: ate:Athe_1055 riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; Belongs to the ribF family. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.461 |
| ADQ04808.1 | hisA | Calow_1250 | Calow_1253 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.494 |
| ADQ04808.1 | hisB | Calow_1250 | Calow_1255 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | KEGG: ate:Athe_1476 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.482 |
| ADQ04808.1 | hisF | Calow_1250 | Calow_1252 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.529 |
| ADQ04808.1 | hisH | Calow_1250 | Calow_1254 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.500 |
| ADQ04808.1 | hisI | Calow_1250 | Calow_1251 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | KEGG: ate:Athe_1472 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. | 0.529 |
| ADQ04808.1 | murJ-2 | Calow_1250 | Calow_1249 | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.660 |
| ADQ05282.1 | murJ-2 | Calow_1744 | Calow_1249 | Polysaccharide pyruvyl transferase CsaB; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.429 |
| hisA | ADQ04808.1 | Calow_1253 | Calow_1250 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | 0.494 |
| hisA | hisB | Calow_1253 | Calow_1255 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | KEGG: ate:Athe_1476 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.998 |
| hisA | hisF | Calow_1253 | Calow_1252 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisA | hisH | Calow_1253 | Calow_1254 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | Calow_1253 | Calow_1251 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | KEGG: ate:Athe_1472 phosphoribosyl-ATP diphosphatase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
| hisA | murJ-2 | Calow_1253 | Calow_1249 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.416 |
| hisB | ADQ04808.1 | Calow_1255 | Calow_1250 | KEGG: ate:Athe_1476 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | KEGG: ate:Athe_1471 mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; mannose-6-phosphate isomerase type II. | 0.482 |
| hisB | hisA | Calow_1255 | Calow_1253 | KEGG: ate:Athe_1476 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ate:Athe_1474 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.998 |