Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ADQ04916.1PFAM: protein of unknown function DUF633; KEGG: ate:Athe_1620 protein of unknown function DUF633. (221 aa)    
Predicted Functional Partners:
ADQ04915.1
PFAM: protein of unknown function DUF34; KEGG: ate:Athe_1619 protein of unknown function DUF34; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
  
  
 0.960
ADQ04562.1
PFAM: protein of unknown function DUF965; KEGG: ate:Athe_1208 protein of unknown function DUF965; Belongs to the UPF0297 family.
  
     0.736
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
       0.650
ADQ04913.1
PFAM: ABC-1 domain-containing protein; aminoglycoside phosphotransferase; KEGG: ate:Athe_1617 ABC-1 domain protein.
       0.645
ADQ04692.1
KEGG: ate:Athe_1338 polysaccharide biosynthesis protein; manually curated; PFAM: polysaccharide biosynthesis protein.
  
     0.618
ADQ04912.1
KEGG: ate:Athe_1616 hypothetical protein.
       0.595
ADQ04320.1
Helix-turn-helix protein YlxM/p13 family protein; Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
  
     0.545
ADQ04917.1
KEGG: ate:Athe_1621 hypothetical protein.
       0.545
ADQ04292.1
Phosphoesterase RecJ domain protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family.
  
     0.521
ADQ04235.1
PFAM: Uncharacterised protein family UPF0029, Impact, N-terminal; Uncharacterised protein family UPF0029, Impact, C-terminal; KEGG: ate:Athe_0813 protein of unknown function UPF0029.
   
    0.518
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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