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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCProtein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (373 aa)    
Predicted Functional Partners:
ADQ04933.1
PFAM: PP-loop domain protein; KEGG: ate:Athe_1637 PP family ATPase.
 
 0.989
ADQ04932.1
PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; KEGG: ate:Athe_1636 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase.
 
  
 0.981
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
       0.626
ADQ04934.1
PFAM: Aldose 1-epimerase; KEGG: ate:Athe_1638 aldose 1-epimerase.
       0.612
ADQ04280.1
PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: cac:CAC0771 cobalt transport protein CbiM.
 
    0.599
ADQ04936.1
KEGG: ate:Athe_1640 hypothetical protein.
       0.477
ADQ05435.1
KEGG: ate:Athe_2219 4Fe-4S ferredoxin iron-sulfur binding domain protein.
 
    0.434
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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