node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADQ05401.1 | codY | Calow_1872 | Calow_1867 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.641 |
ADQ05401.1 | hslU | Calow_1872 | Calow_1868 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.735 |
ADQ05401.1 | hslV | Calow_1872 | Calow_1869 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.775 |
ADQ05401.1 | rtcB | Calow_1872 | Calow_1873 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.687 |
ADQ05401.1 | topA | Calow_1872 | Calow_1871 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.912 |
ADQ05401.1 | trmFO | Calow_1872 | Calow_1870 | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | Gid protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.791 |
ADQ05403.1 | rtcB | Calow_1874 | Calow_1873 | KEGG: ate:Athe_2185 radical SAM domain protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.418 |
ADQ05415.1 | rtcB | Calow_1886 | Calow_1873 | PFAM: tRNA pseudouridine synthase D TruD; KEGG: ate:Athe_2197 tRNA pseudouridine synthase D TruD. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.407 |
ADQ05724.1 | rtcB | Calow_2221 | Calow_1873 | PFAM: Rhomboid family protein; KEGG: ate:Athe_2713 rhomboid family protein. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.414 |
codY | ADQ05401.1 | Calow_1867 | Calow_1872 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | 0.641 |
codY | hslU | Calow_1867 | Calow_1868 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.819 |
codY | hslV | Calow_1867 | Calow_1869 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.785 |
codY | rtcB | Calow_1867 | Calow_1873 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.438 |
codY | topA | Calow_1867 | Calow_1871 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.809 |
codY | trmFO | Calow_1867 | Calow_1870 | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Gid protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. | 0.675 |
hslU | ADQ05401.1 | Calow_1868 | Calow_1872 | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | KEGG: ate:Athe_2182 DNA protecting protein DprA; TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein. | 0.735 |
hslU | codY | Calow_1868 | Calow_1867 | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | GTP-sensing pleiotropic transcriptional repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.819 |
hslU | hslV | Calow_1868 | Calow_1869 | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.999 |
hslU | rtcB | Calow_1868 | Calow_1873 | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | PFAM: protein of unknown function UPF0027; KEGG: ate:Athe_2183 protein of unknown function UPF0027; Belongs to the RtcB family. | 0.550 |
hslU | topA | Calow_1868 | Calow_1871 | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.854 |