Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ05405.1Ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: ate:Athe_2189 ferric uptake regulator, Fur family. (140 aa)    
Predicted Functional Partners:
ADQ05407.1
KEGG: ate:Athe_2191 ABC transporter related; PFAM: ABC transporter related; SMART: AAA ATPase.
  
  
 0.873
ADQ05406.1
PFAM: periplasmic solute binding protein; KEGG: ate:Athe_2190 periplasmic solute binding protein.
 
  
 0.871
ADQ05408.1
PFAM: ABC-3 protein; KEGG: ate:Athe_2192 ABC-3 protein.
 
  
 0.864
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.568
ADQ03633.1
Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  
  
 0.552
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.530
ADQ04055.1
KEGG: ate:Athe_0605 hypothetical protein.
  
    0.527
sigA
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
  
 
 0.521
ADQ04390.1
RNA polymerase, sigma 70 subunit, RpoD subfamily; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
 
 0.521
ADQ04370.1
KEGG: ate:Athe_1015 CoA-binding domain protein; manually curated; PFAM: CoA-binding domain protein.
  
    0.512
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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