Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
ADQ05545.1PFAM: integrase family protein; integrase domain protein SAM domain protein; KEGG: tit:Thit_1881 integrase family protein; Belongs to the 'phage' integrase family. (291 aa)    
Predicted Functional Partners:
ADQ04334.1
Manually curated; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; KEGG: ate:Athe_0980 cell divisionFtsK/SpoIIIE; SMART: AAA ATPase.
 
   
 0.598
rpsF
Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA.
  
 
 
 0.580
ADQ04967.1
PFAM: phosphoribosyltransferase; KEGG: ate:Athe_1679 phosphoribosyltransferase.
  
    0.574
rplY
Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
 
 
   0.567
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
  
 0.537
rpsU
KEGG: csc:Csac_1833 ribosomal protein S21; TIGRFAM: ribosomal protein S21; PFAM: ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family.
   
 
 0.519
rpsI
PFAM: ribosomal protein S9; KEGG: ate:Athe_2069 ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
    
 
 0.518
rpmG
KEGG: ate:Athe_1534 ribosomal protein L33; TIGRFAM: ribosomal protein L33; PFAM: ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.
    
 
 0.513
rpsO
Ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
   
 
 0.507
rpsR
Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.
   
 
 0.503
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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