Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADQ05603.1KEGG: ate:Athe_2365 hypothetical protein. (180 aa)    
Predicted Functional Partners:
ADQ05498.1
PFAM: DNA polymerase beta domain protein region; KEGG: csc:Csac_0229 DNA polymerase beta subunit.
 
    0.608
ADQ03792.1
PFAM: Conserved hypothetical protein CHP02678; KEGG: ate:Athe_0248 hypothetical protein.
 
 
   0.605
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.595
ADQ05585.1
PFAM: DNA polymerase beta domain protein region; KEGG: ate:Athe_2345 DNA polymerase beta domain protein region.
 
    0.581
ADQ05602.1
PFAM: sodium/calcium exchanger membrane region; KEGG: ate:Athe_2364 sodium/calcium exchanger membrane region.
   
   0.571
ADQ05411.1
PFAM: DNA polymerase beta domain protein region; KEGG: ate:Athe_2195 DNA polymerase beta domain protein region.
  
     0.565
scpA
Chromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
 
 0.562
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.558
ADQ03768.1
PFAM: DNA polymerase beta domain protein region; KEGG: csc:Csac_0123 DNA polymerase beta subunit.
 
    0.517
ADQ05607.1
KEGG: ate:Athe_2369 hypothetical protein.
 
     0.515
Your Current Organism:
Caldicellulosiruptor owensensis
NCBI taxonomy Id: 632518
Other names: C. owensensis OL, Caldicellulosiruptor owensensis DSM 13100, Caldicellulosiruptor owensensis OL, Caldicellulosiruptor owensensis str. OL, Caldicellulosiruptor owensensis strain OL
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