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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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pupPutative proteasome accessory factor; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. (64 aa)    
Predicted Functional Partners:
arc
ATPase ARC; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
 
 
 0.991
prcA
20S proteasome alpha-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
 
   
 0.980
prcB
20S proteasome beta-type subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
 
   
 0.980
ROP_05840
Putative proteasome accessory factor.
 
  
 0.926
pafA
Proteasome accessory factor A; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
 
  
 0.909
ROP_39790
Hypothetical protein.
  
   
 0.711
ROP_69800
Putative ABC transporter permease protein.
  
     0.580
clpS
Putative ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
     0.552
ROP_69700
Hypothetical membrane protein.
  
     0.530
ctaF
Putative cytochrome c oxidase subunit IV; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
  
     0.454
Your Current Organism:
Rhodococcus opacus
NCBI taxonomy Id: 632772
Other names: R. opacus B4, Rhodococcus opacus B4, Rhodococcus opacus str. B4, Rhodococcus opacus strain B4
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