clpC protein (Rhodococcus opacus) - STRING interaction network

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clpC

ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (845 aa)

Predicted Functional Partners:

clpP

0.857

grpE

0.808

grpE-2

0.806

clpP-2

0.790

clpP-3

0.784

clpS

0.780

ROP_47210

0.771

dnaK

0.763

dnaK-2

0.761

groES

0.731

Your Current Organism:

Rhodococcus opacus

NCBI taxonomy Id: 632772
Other names: R. opacus B4, Rhodococcus opacus B4, Rhodococcus opacus str. B4, Rhodococcus opacus strain B4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ROP_47210	clpC	ROP_47210	ROP_43390	Peptidase S14 family protein; Belongs to the peptidase S14 family.	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	0.771
ROP_47210	clpP	ROP_47210	ROP_10870	Peptidase S14 family protein; Belongs to the peptidase S14 family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.973
ROP_47210	clpS	ROP_47210	ROP_11500	Peptidase S14 family protein; Belongs to the peptidase S14 family.	Putative ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.585
ROP_47210	dnaK	ROP_47210	ROP_01550	Peptidase S14 family protein; Belongs to the peptidase S14 family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.566
ROP_47210	dnaK-2	ROP_47210	ROP_55720	Peptidase S14 family protein; Belongs to the peptidase S14 family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.566
ROP_47210	groES	ROP_47210	ROP_62490	Peptidase S14 family protein; Belongs to the peptidase S14 family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.834
ROP_47210	grpE	ROP_47210	ROP_01560	Peptidase S14 family protein; Belongs to the peptidase S14 family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.589
ROP_47210	grpE-2	ROP_47210	ROP_55730	Peptidase S14 family protein; Belongs to the peptidase S14 family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.589
clpC	ROP_47210	ROP_43390	ROP_47210	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Peptidase S14 family protein; Belongs to the peptidase S14 family.	0.771
clpC	clpP	ROP_43390	ROP_10870	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.857
clpC	clpP-2	ROP_43390	ROP_10880	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.790
clpC	clpP-3	ROP_43390	ROP_12300	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	0.784
clpC	clpS	ROP_43390	ROP_11500	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Putative ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.	0.780
clpC	dnaK	ROP_43390	ROP_01550	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.763
clpC	dnaK-2	ROP_43390	ROP_55720	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.761
clpC	groES	ROP_43390	ROP_62490	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.731
clpC	grpE	ROP_43390	ROP_01560	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.808
clpC	grpE-2	ROP_43390	ROP_55730	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.806
clpP	ROP_47210	ROP_10870	ROP_47210	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	Peptidase S14 family protein; Belongs to the peptidase S14 family.	0.973
clpP	clpC	ROP_10870	ROP_43390	ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.	ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family.	0.857