STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ROP_44760Putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (595 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.989
ROP_48970
Tartrate dehydrogenase/tartrate decarboxylase/D-malate dehydrogenase; Multifunctional protein.
 
 0.965
ilvN
Acetolactate synthase small subunit; Protein synonym:acetohydroxyacid synthase.
 
 
 0.956
ROP_28310
Putative 4-carboxy-4-hydroxy-2-oxoadipate aldolase.
 
  
 0.917
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 0.890
ROP_07140
Putative 3-isopropylmalate dehydrogenase.
 
 0.877
ROP_61310
Putative oxidoreductase.
  
 
 0.877
poxB
Protein synonym:pyruvate oxidase; Belongs to the TPP enzyme family.
 
  
0.854
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.854
ilvA
Protein synonym:threonine deaminase.
 
 0.850
Your Current Organism:
Rhodococcus opacus
NCBI taxonomy Id: 632772
Other names: R. opacus B4, Rhodococcus opacus B4, Rhodococcus opacus str. B4, Rhodococcus opacus strain B4
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