STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
 
 0.995
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Bifunctional protein.
 
 0.991
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.990
ROP_62600
IMP dehydrogenase family protein.
 
 
 0.981
hpt
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.974
guaA
GMP synthetase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.974
ROP_70270
Putative inosine-5'-monophosphate dehydrogenase; Protein synonym:IMP dehydrogenase.
 
 
 0.973
pyrB
Protein synonym:aspartate transcarbamylase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.955
argG
Argininosuccinate synthase; Protein synonym:citrulline--aspartate ligase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  
 
 0.945
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
 
  
 0.933
Your Current Organism:
Rhodococcus opacus
NCBI taxonomy Id: 632772
Other names: R. opacus B4, Rhodococcus opacus B4, Rhodococcus opacus str. B4, Rhodococcus opacus strain B4
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