EET46288.1 protein (Thalassobium sp. R2A62) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

EET46288.1

Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547. (293 aa)

Predicted Functional Partners:

EET49882.1

0.689

EET47319.1

0.688

EET48566.1

0.660

EET49438.1

0.660

Your Current Organism:

Thalassobium sp. R2A62

NCBI taxonomy Id: 633131
Other names: T. sp. R2A62, Thalassiobium sp. R2A62, alpha proteobacterium R2A62

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EET46288.1	EET47319.1	TR2A62_2340	TR2A62_2339	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	Hemimethylated DNA binding protein; Identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097.	0.688
EET46288.1	EET48566.1	TR2A62_2340	TR2A62_2587	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	NADP-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.660
EET46288.1	EET49438.1	TR2A62_2340	TR2A62_3424	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	NAD-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.660
EET46288.1	EET49882.1	TR2A62_2340	TR2A62_2341	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	Hypothetical protein.	0.689
EET47319.1	EET46288.1	TR2A62_2339	TR2A62_2340	Hemimethylated DNA binding protein; Identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097.	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	0.688
EET47319.1	EET49882.1	TR2A62_2339	TR2A62_2341	Hemimethylated DNA binding protein; Identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097.	Hypothetical protein.	0.655
EET48566.1	EET46288.1	TR2A62_2587	TR2A62_2340	NADP-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	0.660
EET48566.1	EET49438.1	TR2A62_2587	TR2A62_3424	NADP-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	NAD-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.819
EET49438.1	EET46288.1	TR2A62_3424	TR2A62_2340	NAD-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	0.660
EET49438.1	EET48566.1	TR2A62_3424	TR2A62_2587	NAD-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	NADP-dependent malic enzyme; Identified by match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.819
EET49882.1	EET46288.1	TR2A62_2341	TR2A62_2340	Hypothetical protein.	Auxin efflux carrier family protein; Identified by match to protein family HMM PF03547.	0.689
EET49882.1	EET47319.1	TR2A62_2341	TR2A62_2339	Hypothetical protein.	Hemimethylated DNA binding protein; Identified by match to protein family HMM PF08755; match to protein family HMM TIGR02097.	0.655

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

18

PPI enrichment p-value:

4.94e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035556

Intracellular signal transduction

6 of 251

1.49

1.72

2.45e-05

GO:0007165

Signal transduction

7 of 427

1.32

1.5

2.45e-05

GO:0010737

Protein kinase A signaling

2 of 4

2.81

1.38

0.0031

GO:0006796

Phosphate-containing compound metabolic process

6 of 765

1.0

0.77

0.0032

GO:0048519

Negative regulation of biological process

5 of 541

1.07

0.73

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004690

Cyclic nucleotide-dependent protein kinase activity

4 of 5

3.01

4.05

3.74e-08

GO:0004679

AMP-activated protein kinase activity

3 of 3

3.11

2.91

5.24e-06

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.98

2.86

6.11e-06

GO:0019003

GDP binding

2 of 3

2.93

1.48

0.0021

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 544

1.07

0.79

0.0045

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 4

2.81

1.21

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3280

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

5 of 16

2.6

4.43

3.23e-09

CL:3208

Mixed, incl. Peptidyl-serine phosphorylation, and Aquaporin-mediated transport

6 of 52

2.17

3.99

3.23e-09

CL:3282

Mixed, incl. Cyclic nucleotide-dependent protein kinase activity, and AKT phosphorylates targets in the nucleus

4 of 11

2.67

3.66

1.31e-07

CL:3285

G protein activity, and Cyclic nucleotide-dependent protein kinase activity

3 of 5

2.89

2.8

7.61e-06

CL:2922

Protein kinase domain, and GTPase regulator activity

7 of 196

1.66

2.76

2.32e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

4 of 131

1.59

1.5

0.00035

map04138

Autophagy - yeast

3 of 150

1.41

0.84

0.0135

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9634597

GPER1 signaling

3 of 4

2.98

2.88

5.70e-06

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 4

2.98

2.88

5.70e-06

MAP-164378

PKA activation in glucagon signalling

3 of 4

2.98

2.88

5.70e-06

MAP-163615

PKA activation

3 of 4

2.98

2.88

5.70e-06

MAP-163359

Glucagon signaling in metabolic regulation

3 of 4

2.98

2.88

5.70e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.89

2.59

1.86e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

2 of 4

2.81

0.91

0.0225

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

2 of 3

2.93

1.53

0.0017

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