EET48232.1 protein (Thalassobium sp. R2A62) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EET48232.1

OmpA/MotB domain protein; Identified by match to protein family HMM PF00691. (725 aa)

Predicted Functional Partners:

EET46783.1

0.999

EET47073.1

0.960

EET47463.1

0.909

flgC

0.909

EET48160.1

0.872

EET49522.1

0.870

flgK

0.854

fliL

0.840

EET46486.1

0.838

flhA

0.820

Your Current Organism:

Thalassobium sp. R2A62

NCBI taxonomy Id: 633131
Other names: T. sp. R2A62, Thalassiobium sp. R2A62, alpha proteobacterium R2A62

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EET46486.1	EET46783.1	TR2A62_2688	TR2A62_2674	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	0.930
EET46486.1	EET47463.1	TR2A62_2688	TR2A62_0385	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Flagellar motor switch protein FliG; Identified by match to protein family HMM PF01706.	0.994
EET46486.1	EET48160.1	TR2A62_2688	TR2A62_0797	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Chemotaxis protein CheA.	0.898
EET46486.1	EET48232.1	TR2A62_2688	TR2A62_3299	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	OmpA/MotB domain protein; Identified by match to protein family HMM PF00691.	0.838
EET46486.1	EET49522.1	TR2A62_2688	TR2A62_2662	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	OmpA/MotB.	0.856
EET46486.1	flgC	TR2A62_2688	TR2A62_2687	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Flagellar basal-body rod protein FlgC; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR01395; Belongs to the flagella basal body rod proteins family.	0.986
EET46486.1	flgK	TR2A62_2688	TR2A62_2664	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Flagellar hook-associated protein FlgK; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02492; Belongs to the flagella basal body rod proteins family.	0.964
EET46486.1	flhA	TR2A62_2688	TR2A62_2676	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.	0.988
EET46486.1	fliL	TR2A62_2688	TR2A62_2671	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.	0.877
EET46783.1	EET46486.1	TR2A62_2674	TR2A62_2688	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	0.930
EET46783.1	EET47463.1	TR2A62_2674	TR2A62_0385	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellar motor switch protein FliG; Identified by match to protein family HMM PF01706.	0.987
EET46783.1	EET48160.1	TR2A62_2674	TR2A62_0797	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Chemotaxis protein CheA.	0.926
EET46783.1	EET48232.1	TR2A62_2674	TR2A62_3299	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	OmpA/MotB domain protein; Identified by match to protein family HMM PF00691.	0.999
EET46783.1	EET49522.1	TR2A62_2674	TR2A62_2662	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	OmpA/MotB.	0.999
EET46783.1	flgC	TR2A62_2674	TR2A62_2687	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellar basal-body rod protein FlgC; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR01395; Belongs to the flagella basal body rod proteins family.	0.993
EET46783.1	flgK	TR2A62_2674	TR2A62_2664	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellar hook-associated protein FlgK; Identified by match to protein family HMM PF00460; match to protein family HMM PF06429; match to protein family HMM TIGR02492; Belongs to the flagella basal body rod proteins family.	0.991
EET46783.1	flhA	TR2A62_2674	TR2A62_2676	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.	0.959
EET46783.1	fliL	TR2A62_2674	TR2A62_2671	Chemotaxis protein MotA; Identified by match to protein family HMM PF01618.	Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.	0.996
EET47073.1	EET48232.1	TR2A62_3297	TR2A62_3299	MotA/TolQ/ExbB proton channel family protein.	OmpA/MotB domain protein; Identified by match to protein family HMM PF00691.	0.960
EET47463.1	EET46486.1	TR2A62_0385	TR2A62_2688	Flagellar motor switch protein FliG; Identified by match to protein family HMM PF01706.	Flagellum-specific ATP synthase; Identified by match to protein family HMM PF00006; match to protein family HMM TIGR01026.	0.994

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

0.0208

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

11 of 388

0.97

1.14

3.22e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015099

Nickel cation transmembrane transporter activity

10 of 20

2.21

7.28

2.19e-18

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 636

0.75

7.24e-07

GO:0016021

Integral component of membrane

11 of 683

0.72

0.71

7.24e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4332

Quorum sensing, and Oligopeptide/dipeptide transporter, C-terminal region

11 of 59

1.78

4.84

5.43e-17

CL:4333

Quorum sensing

10 of 50

1.81

4.71

2.24e-15

CL:4334

Quorum sensing

9 of 41

1.86

4.57

7.96e-14

CL:4335

Quorum sensing

6 of 30

1.81

3.01

3.94e-08

CL:4336

Nickel cation transmembrane transporter activity, and Peptide transport

5 of 25

1.81

2.52

1.48e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fpla02024

Quorum sensing

10 of 66

1.69

4.05

1.05e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

11 of 70

1.71

4.58

5.92e-18

MAP-9635486

Infection with Mycobacterium tuberculosis

11 of 90

1.6

3.9

3.88e-17

MAP-5663205

Infectious disease

11 of 97

1.57

3.72

5.61e-17

MAP-1643685

Disease

11 of 97

1.57

3.72

5.61e-17

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

9 of 104

1.45

2.53

2.67e-10

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0813

Transport

7 of 142

1.21

1.38

9.77e-06

KW-1003

Cell membrane

7 of 154

1.17

1.33

9.77e-06

KW-1133

Transmembrane helix

8 of 594

0.64

0.48

0.0038

KW-0812

Transmembrane

8 of 594

0.64

0.48

0.0038

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

10 of 43

1.88

5.07

1.12e-15

PF12911

N-terminal TM domain of oligopeptide transport permease C

5 of 6

2.43

4.05

1.11e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035906

MetI-like superfamily

7 of 37

1.79

3.14

9.63e-09

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

7 of 38

1.78

3.11

9.63e-09

IPR025966

Oligopeptide transport permease C-like, N-terminal domain

3 of 4

2.39

1.88

0.00030

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