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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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[Homology]
Score
Olsu_0804COGs: COG0262 Dihydrofolate reductase; InterPro IPR001796:IPR012259; KEGG: apv:Apar_0631 dihydrofolate reductase region; PFAM: dihydrofolate reductase region; SPTR: C8WAC3 Dihydrofolate reductase region; PFAM: Dihydrofolate reductase. (181 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 
 0.997
Olsu_0794
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR013221:IPR004101:IPR001645; KEGG: apv:Apar_0625 FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: B9CJX4 Folylpolyglutamate synthase; TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase.
     
 0.926
fhs
Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR000559:IPR020628; KEGG: apv:Apar_0621 formate--tetrahydrofolate ligase; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: B9CK23 Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase.
  
 
 0.919
Olsu_0338
IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR013982; KEGG: shi:Shel_23860 AICAR transformylase/IMP cyclohydrolase PurH; PFAM: AICARFT/IMPCHase bienzyme formylation region; PRIAM: IMP cyclohydrolase; SMART: AICARFT/IMPCHase bienzyme formylation region; SPTR: C7N1V4 AICAR transformylase/IMP cyclohydrolase PurH; PFAM: AICARFT/IMPCHase bienzyme.
    
 0.913
purN
Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.912
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.736
clpP
ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
    
 
 0.693
Olsu_0101
COGs: COG0294 Dihydropteroate synthase; InterPro IPR011005:IPR000550:IPR006390:IPR000489; KEGG: apv:Apar_0111 dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS; 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; SPTR: B9CMA7 Dihydropteroate synthase 1; TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: Pterin binding enzyme; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: dihydropteroate synthase; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase.
     
 0.610
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR011994:IPR002123:IPR003136; KEGG: apv:Apar_0725 cytidylate kinase; PFAM: cytidylate kinase region; phospholipid/glycerol acyltransferase; SMART: phospholipid/glycerol acyltransferase; SPTR: B9CKD8 Bifunctional pantoate ligase/cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: Cytidylate kinase; Acyltransferase; TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferases; cytidylate kinase.
  
  
 0.538
Olsu_0846
Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterPro IPR020822:IPR001086:IPR002912:IPR002701; KEGG: drm:Dred_0783 prephenate dehydratase; PFAM: prephenate dehydratase; Chorismate mutase, type II; amino acid-binding ACT domain protein; PRIAM: Chorismate mutase; SPTR: C2D675 Possible chorismate mutase; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II; TIGRFAM: monofunctional chorismate mutase, gram positive-type, clade 2.
     
 0.526
Your Current Organism:
Olsenella uli
NCBI taxonomy Id: 633147
Other names: O. uli DSM 7084, Olsenella uli ATCC 49627, Olsenella uli DSM 7084, Olsenella uli str. DSM 7084, Olsenella uli strain DSM 7084
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