Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Tagg_0010Hypothetical protein; SPTR: B8D6I1 Putative uncharacterized protein; PFAM: ThiS family. (67 aa)    
Predicted Functional Partners:
Tagg_0011
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR007901:IPR000594; KEGG: wsu:WS1006 molybdopterin biosynthesis protein MoeB; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: B8D6I2 MoeB/thiF molybdopterin or thiamine synthase protein; PFAM: MoeZ/MoeB domain; ThiF family.
  
 
 0.978
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.892
Tagg_0777
Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR013749:IPR004399; KEGG: sfu:Sfum_1692 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; SPTR: B8D4K9 Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase.
  
  
 0.844
Tagg_0009
Ras superfamily GTP-binding protein YlqF; COGs: COG1161 GTPase; InterPro IPR002917; KEGG: nucleolar GTPase; PFAM: GTP-binding protein HSR1-related; SPTR: B8D6I0 GTP-binding protein, HSR1-related; PFAM: GTPase of unknown function; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
       0.748
Tagg_0008
Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
       0.745
Tagg_0617
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: scl:sce0669 sarcosine oxidase, beta subunit; PFAM: FAD dependent oxidoreductase; SPTR: B8D2Y9 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
  
  
 0.643
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
  
    0.612
Tagg_0461
COGs: COG4721 membrane protein; InterPro IPR017195; PFAM: ABC-type thiamin-related transport system, permease component 1, predicted; SPTR: B8D6R0 ABC transporter, permease protein; PFAM: ABC-type cobalt transport system, permease component.
  
    0.587
Tagg_0007
Radical SAM domain protein; COGs: COG1964 Fe-S oxidoreductase; InterPro IPR007197:IPR000385; KEGG: afw:Anae109_0183 radical SAM domain-containing protein; PFAM: Radical SAM domain protein; SPTR: B8D6H8 Predicted Fe-S oxidoreductase; PFAM: Radical SAM superfamily.
       0.536
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
Server load: low (12%) [HD]