STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tagg_0088COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644; KEGG: bac:BamMC406_6220 signal-transduction protein; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: B8D331 Putative signal-transduction protein with CBS domain; PFAM: CBS domain. (141 aa)    
Predicted Functional Partners:
Tagg_0780
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR006220:IPR011702:IPR001317:IPR001674:IPR 000991:IPR004739; KEGG: mes:Meso_0495 GMP synthase; PFAM: glutamine amidotransferase class-I; GMP synthase domain protein; PRIAM: GMP synthase (glutamine-hydrolyzing); SPTR: B8D3X4 GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
 
 0.866
Tagg_0410
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR000103:IPR000815:IPR001327:IPR 004099:IPR006076:IPR006258; KEGG: scl:sce8000 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; SPTR: B8D2P1 Dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxi [...]
  
 
 0.733
Tagg_0090
NUDIX hydrolase; InterPro IPR000086:IPR020084:IPR004385; KEGG: pca:Pcar_0414 NTP pyrophosphohydrolase; PFAM: NUDIX hydrolase; SPTR: B8D5D2 ADP-ribose pyrophosphatase; PFAM: NUDIX domain; TIGRFAM: nudix hydrolase, YffH family.
  
  
 0.639
Tagg_0141
Protein of unknown function ATP binding protein; COGs: COG1100 GTPase SAR1 and related small G protein; InterPro IPR004130; KEGG: hypothetical protein; K06883; PFAM: protein of unknown function ATP binding; SPTR: B8D437 Predicted ATP binding protein; PFAM: Conserved hypothetical ATP binding protein.
  
 0.626
Tagg_0213
InterPro IPR004130; KEGG: hypothetical protein; K06883; PFAM: protein of unknown function ATP binding; SPTR: B8D2L6 Putative uncharacterized protein; PFAM: Conserved hypothetical ATP binding protein.
  
 0.626
Tagg_0089
Hypothetical protein; SPTR: A3DNR5 Putative uncharacterized protein.
       0.590
Tagg_0084
V-type ATPase 116 kDa subunit; COGs: COG1269 H+-ATPase subunit I; InterPro IPR002490; KEGG: gur:Gura_0418 H(+)-transporting two-sector ATPase; PFAM: V-type ATPase 116 kDa subunit; SPTR: B8D5D7 V-type ATPase, 116 kDa subunit I; PFAM: V-type ATPase 116kDa subunit family.
  
    0.578
Tagg_0092
CDP-alcohol phosphatidyltransferase; COGs: COG0558 Phosphatidylglycerophosphate synthase; InterPro IPR000462; KEGG: ank:AnaeK_2943 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; SPTR: B8D5D0 CDP-alcohol phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.574
Tagg_0201
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644; KEGG: reu:Reut_A0040 CBS; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: B8D6R7 Putative signal transduction protein with CBS domain; PFAM: CBS domain.
 
    0.562
Tagg_0087
COGs: COG1394 H+-ATPase subunit D; InterPro IPR002699:IPR018483; KEGG: similar to vacuolar proton pump delta polypeptide; K02149 V-type H+-transporting ATPase subunit D; PFAM: H+transporting two-sector ATPase D subunit; SPTR: A3DNR4 V-type ATPase, D subunit; TIGRFAM: V-type ATPase, D subunit; PFAM: ATP synthase subunit D; TIGRFAM: H(+)-transporting ATP synthase, vacuolar type, subunit D.
       0.556
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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