STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPBGlycine dehydrogenase (decarboxylating) beta subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (519 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
  
 0.999
Tagg_0407
Aminomethyltransferase; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterPro IPR013977:IPR006222:IPR006223; KEGG: pub:SAR11_0666 glycine cleavage system protein T2; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; SPTR: B8D2P4 Aminomethyltransferase; TIGRFAM: glycine cleavage system T protein; PFAM: Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein.
 0.999
gcvPA
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
0.999
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.989
Tagg_0410
COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR000103:IPR000815:IPR001327:IPR 004099:IPR006076:IPR006258; KEGG: scl:sce8000 pyruvate dehydrogenase E3 (dihydrolipoamide dehydrogenase); PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; SPTR: B8D2P1 Dihydrolipoamide dehydrogenase; TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxi [...]
  
 
 0.989
Tagg_1095
2-amino-3-ketobutyrate coenzyme A ligase; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839:IPR001917; KEGG: gbm:Gbem_0049 pyridoxal phosphate-dependent acyltransferase; PFAM: aminotransferase class I and II; PRIAM: Glycine C-acetyltransferase; SPTR: B8D4W3 Pyridoxal phosphate-dependent acyltransferase, putative; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase; pyridoxal phosphate-dependent acyltransferase, putative.
  
 
 0.938
Tagg_0617
FAD dependent oxidoreductase; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: scl:sce0669 sarcosine oxidase, beta subunit; PFAM: FAD dependent oxidoreductase; SPTR: B8D2Y9 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase.
  
 
 0.932
Tagg_0620
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG0492 Thioredoxin reductase; InterProIPR000759:IPR013027:IPR000103:IPR001327:IPR 006058:IPR001041; KEGG: dat:HRM2_04900 SoxA1; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: B8D2Y6 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase.
   
 
 0.926
Tagg_1073
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096; KEGG: nmc:NMC1413 putative glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: B8D6P6 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 0.882
Tagg_0520
COGs: COG0174 Glutamine synthetase; InterPro IPR008146; KEGG: wbr:WGLp589 hypothetical protein; PFAM: glutamine synthetase catalytic region; SPTR: A3DKY6 L-glutamine synthetase; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.
  
 
 0.873
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.