STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tagg_0668Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR001176:IPR004839:IPR004838; KEGG: sfu:Sfum_3898 aminotransferase, class I and II; PFAM: aminotransferase class I and II; SPTR: B8D3W3 Aspartate aminotransferase (AspC), conjectural; PFAM: Aminotransferase class I and II. (398 aa)    
Predicted Functional Partners:
Tagg_1073
COGs: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; InterPro IPR006095:IPR006097:IPR006096; KEGG: nmc:NMC1413 putative glutamate dehydrogenase; PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; SPTR: B8D6P6 Glu/Leu/Phe/Val dehydrogenase, C terminal; PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.967
Tagg_0191
COGs: COG0076 Glutamate decarboxylase and related PLP-dependent protein; InterPro IPR000310:IPR001597:IPR000192:IPR002129; KEGG: swd:Swoo_2007 pyridoxal-dependent decarboxylase; PFAM: Pyridoxal-dependent decarboxylase; aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; Orn/Lys/Arg decarboxylase major region; SPTR: B8D379 Pyridoxal-dependent decarboxylase; PFAM: Pyridoxal-dependent decarboxylase conserved domain.
  
 
 0.947
Tagg_0239
COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR001216; KEGG: hypothetical protein; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: B8D3M3 Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme.
 
 0.944
Tagg_1314
Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR010916; KEGG: cysteine synthases family protein; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: A1RVD0 Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme.
 
 0.944
Tagg_0059
Sulfide dehydrogenase (flavoprotein) subunit SudA; COGs: COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductase; InterPro IPR000759:IPR013027:IPR000103:IPR001327; KEGG: dvm:DvMF_0446 putative glutamate synthase subunit beta; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: B8D5G0 Putative glutamate synthase subunit beta; PFAM: Pyridine nucleotide-disulphide oxidoreductase.
  
 
 0.942
Tagg_0484
Asparaginase; COGs: COG1446 Asparaginase; InterPro IPR000246; KEGG: sfr:Sfri_1445 peptidase T2, asparaginase 2; PFAM: peptidase T2 asparaginase 2; PRIAM: Beta-aspartyl-peptidase; SPTR: A3DPP6 Asparaginase; PFAM: Asparaginase.
 
 
 0.922
Tagg_0658
COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085:IPR003382:IPR005252; KEGG: gem:GM21_2546 phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein; SPTR: B8D3H7 Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopanto [...]
 
  0.895
Tagg_0533
Carbamoyl-phosphate synthase L chain ATP-binding protein; COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterProIPR003135:IPR005482:IPR005479:IPR013651:IPR 000115:IPR005481:IPR011761:IPR011764; KEGG: bba:Bd3861 pyruvate carboxylase; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; biotin carboxylase domain protein; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; RimK domain protein ATP-grasp; phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A3DKU3 Pyruvate carboxylase subunit A; PFAM: Carbamoy [...]
 
 
 0.886
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
  
 
 0.883
Tagg_0390
2-oxoglutarate ferredoxin oxidoreductase, delta subunit; InterPro IPR001450:IPR017900; KEGG: dal:Dalk_1630 4Fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: B8D431 2-oxoglutarate ferredoxin oxidoreductase, delta subunit.
    
 0.876
Your Current Organism:
Thermosphaera aggregans
NCBI taxonomy Id: 633148
Other names: T. aggregans DSM 11486, Thermosphaera aggregans DSM 11486, Thermosphaera aggregans M11TL, Thermosphaera aggregans str. DSM 11486, Thermosphaera aggregans strain DSM 11486
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